The tick-over theory revisited: Formation and regulation of the soluble alternative complement C3 convertase (C3(H2O)Bb)

Human complement C3b inactivator: isolation, characterization, and demonstration of an absolute requirement for the serum protein beta1H for cleavage of C3b and C4b in solution.

Michael K. Pangburn, Robert D. Schreiber, Hans J. Müller‐Eberhard · The Journal of Experimental Medicine · 1977 · 684 citations · Full text

Life Sciences, Biochemistry, Immunology +14

Structures of complement component C3 provide insights into the function and evolution of immunity

B.J.C. Janssen, Eric G. Huizinga, H.C.A. Raaijmakers et al. · Nature · 2005 · 548 citations · Full text

Life Sciences, Immunology, Molecular Biology +12

Properdin: binding to C3b and stabilization of the C3b-dependent C3 convertase.

Douglas T. Fearon, K. Frank Austen · The Journal of Experimental Medicine · 1975 · 475 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +13

Formation of the initial C3 convertase of the alternative complement pathway. Acquisition of C3b-like activities by spontaneous hydrolysis of the putative thioester in native C3.

Michael K. Pangburn, Robert D. Schreiber, Hans J. Müller‐Eberhard · The Journal of Experimental Medicine · 1981 · 443 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +10

Large scale isolation of functionally active components of the human complement system.

Carl H. Hammer, George H. Wirtz, Lois Renfer et al. · Journal of Biological Chemistry · 1981 · 438 citations · Full text

Life Sciences, Biochemistry, Immunology +12