Concepedia

Complement Protein Processing

Complement Protein Processing is a proteolytic processing mechanism that involves the sequential enzymatic cleavage of complement proteins to activate and regulate components of the innate immune system.

284

Publications

16.4K

Citations

928

Authors

321

Institutions

Publications per year

2017–2026

17

Parents

Publications

284

THE C3-ACTIVATOR SYSTEM: AN ALTERNATE PATHWAY OF COMPLEMENT ACTIVATION

Otto Götze, Hans J. Müller‐Eberhard · The Journal of Experimental Medicine · 1971 · 848 citations

, , +12

Human complement C3b inactivator: isolation, characterization, and demonstration of an absolute requirement for the serum protein beta1H for cleavage of C3b and C4b in solution.

Michael K. Pangburn, Robert D. Schreiber, Hans J. Müller‐Eberhard · The Journal of Experimental Medicine · 1977 · 684 citations · Full text

, , +14

Isolation of a human erythrocyte membrane glycoprotein with decay-accelerating activity for C3 convertases of the complement system.

A Nicholson-Weller, Joseph J. Burge, D T Fearon et al. · The Journal of Immunology · 1982 · 588 citations · Full text

, , +11

Structures of C3b in Complex with Factors B and D Give Insight into Complement Convertase Formation

Federico Forneris, Daniel Ricklin, Jin Wu et al. · Science · 2010 · 277 citations

, , +14

Factor H–related protein 1 (CFHR-1) inhibits complement C5 convertase activity and terminal complex formation

Stefan Heinen, Andrea Hartmann, Nadine Lauer et al. · Blood · 2009 · 270 citations

, , +11

1–5 of 284

Authors

928

  1. HR
    Harvey R. Colten

    Harvard University, United States

    16 publications · 1.2K citations

    16

    h-index

  2. JG
    Jean Gagnon

    Institut de Biologie Structurale, France

    9 publications · 326 citations

    9

    h-index

  3. NM
    Nicole M. Thielens

    Institut de Biologie Structurale, France

    9 publications · 474 citations

    9

    h-index

  4. GG
    Gabriel Goldberger

    Boston Children's Hospital, United States

    8 publications · 549 citations

    8

    h-index

  5. SN
    Shigeharu Nagasawa

    Hokkaido University, Japan

    7 publications · 252 citations

    7

    h-index

1–5 of 928

Institutions

321

  1. Harvard University

    Cambridge, United States

    13 h-index

    37 publications

    3.2K citations

  2. Boston Children's Hospital

    Boston, United States

    12 h-index

    44 publications

    3.4K citations

  3. Scripps Clinic

    La Jolla, United States

    11 h-index

    31 publications

    3.6K citations

  4. Scripps Health

    San Diego, United States

    11 h-index

    32 publications

    3.7K citations

  5. University of Oxford

    Oxford, United Kingdom

    10 h-index

    22 publications

    1K citations

  6. Inserm

    Paris, France

    10 h-index

    37 publications

    1.4K citations

  7. University of Alabama at Birmingham

    Birmingham, United States

    9 h-index

    22 publications

    831 citations

  8. Washington University in St. Louis

    St Louis, United States

    8 h-index

    24 publications

    1.5K citations

1–8 of 321

Venues

  1. Journal of Biological Chemistry

    JBC · 25 publications · 1.4K citations

    23

    h-index

  2. The Journal of Immunology

    JI · 26 publications · 2.2K citations

    22

    h-index

  3. Biochemical Journal

    BJ · 22 publications · 997 citations

    18

    h-index

  4. PubMed

    Repository · 28 publications · 992 citations

    18

    h-index

  5. Proceedings of the National Academy of Sciences

    PNAS · 17 publications · 1.2K citations

    15

    h-index

1–5