Concepedia

Complement-mediated Activation

Complement-Mediated Activation is a biological mechanism within the mast cell activation cascade wherein mast cells are activated through the engagement of complement system components, particularly anaphylatoxins such as C3a and C5a binding to their respective receptors on mast cell surfaces, distinguishing it from other activation pathways that rely on immunoglobulin E or direct pathogen recognition.

1.4K

Publications

87.6K

Citations

6.7K

Authors

1.5K

Institutions

Publications per year

2017–2026

256

Parents

Publications

1.4K

Oxygen radicals mediate endothelial cell damage by complement-stimulated granulocytes. An in vitro model of immune vascular damage.

T Sacks, Charles F. Moldow, P R Craddock et al. · Journal of Clinical Investigation · 1978 · 1.1K citations · Full text

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Complement and Leukocyte-Mediated Pulmonary Dysfunction in Hemodialysis

Philip R. Craddock, Jörg Fehr, Kenneth L. Brigham et al. · New England Journal of Medicine · 1977 · 1K citations

, , +17

Generation of C5a in the absence of C3: a new complement activation pathway

Markus Huber‐Lang, J. Vidya Sarma, Firas S. Zetoune et al. · Nature Medicine · 2006 · 974 citations

, , +7

Activation of the Complement System During and After Cardiopulmonary Bypass Surgery

Peter Bruins, Henk te Velthuis, Aria P. Yazdanbakhsh et al. · Circulation · 1997 · 804 citations

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Molecular Intercommunication between the Complement and Coagulation Systems

Umme Amara, Michael A. Flierl, Daniel Rittirsch et al. · The Journal of Immunology · 2010 · 723 citations · Full text

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1–5 of 1.4K

Authors

6.7K

  1. JD
    John D. Lambris

    University of Pennsylvania, United States

    36 publications · 5.6K citations

    33

    h-index

  2. TE
    Tony E. Hugli

    Scripps Health, United States

    32 publications · 2.9K citations

    26

    h-index

  3. TE
    Tom Eirik Mollnes

    Oslo University Hospital, Norway

    28 publications · 1.3K citations

    23

    h-index

  4. VM
    V. Michael Holers

    University of Colorado Denver, United States

    23 publications · 2.2K citations

    21

    h-index

  5. PG
    Peter Garred

    Rigshospitalet, Denmark

    18 publications · 837 citations

    17

    h-index

1–5 of 6.7K

Institutions

1.5K

  1. University of Pennsylvania

    Philadelphia, United States

    40 h-index

    145 publications

    17.2K citations

  2. Harvard University

    Cambridge, United States

    36 h-index

    161 publications

    13K citations

  3. University of Colorado Denver

    Denver, United States

    26 h-index

    146 publications

    8.7K citations

  4. Scripps Health

    San Diego, United States

    24 h-index

    81 publications

    8.4K citations

  5. Leiden University Medical Center

    Leiden, The Netherlands

    23 h-index

    102 publications

    5.5K citations

  6. University of Oslo

    Oslo, Norway

    23 h-index

    102 publications

    3.7K citations

  7. Scripps Clinic

    La Jolla, United States

    23 h-index

    73 publications

    7.7K citations

  8. Brigham and Women's Hospital

    Boston, United States

    22 h-index

    92 publications

    12.3K citations

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Venues

  1. The Journal of Immunology

    JI · 171 publications · 13.1K citations

    66

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  2. Journal of Biological Chemistry

    JBC · 50 publications · 3.8K citations

    36

    h-index

  3. PubMed

    Repository · 81 publications · 3.3K citations

    34

    h-index

  4. Infection and Immunity

    IAI · 41 publications · 2.8K citations

    31

    h-index

  5. Proceedings of the National Academy of Sciences

    PNAS · 29 publications · 3.7K citations

    27

    h-index

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