Concepedia

Complement System Abnormalities

Complement System Abnormalities is a pathophysiological construct denoting dysregulation or deficiency in the complement cascade, particularly characterized by reduced levels or function of early classical pathway components (e.g., C1q, C4, C2), which distinguishes it from other immune system anomalies by its central role in impairing immune complex clearance and promoting autoimmunity in Systemic Lupus Erythematosus.

1.1K

Publications

60.2K

Citations

4.7K

Authors

1.3K

Institutions

Publications per year

2017–2026

118

Parents

Publications

1.1K

Relative Role of Genetic Complement Abnormalities in Sporadic and Familial aHUS and Their Impact on Clinical Phenotype

Marina Noris, Jessica Caprioli, Elena Bresin et al. · Clinical Journal of the American Society of Nephrology · 2010 · 1K citations · Full text

, , +13

C1q binds directly and specifically to surface blebs of apoptotic human keratinocytes: complement deficiency and systemic lupus erythematosus revisited

Laura C Korb, J M Ahearn · The Journal of Immunology · 1997 · 659 citations · Full text

, , +17

C3 glomerulopathy: consensus report

Matthew C. Pickering, Vivette D. D’Agati, Carla Nester et al. · Kidney International · 2013 · 641 citations · Full text

, , +17

Complement deficiency states and infection: epidemiology, pathogenesis and consequences of neisserial and other infections in an immune deficiency.

Stephen C. Ross, Peter Densen · PubMed · 1984 · 633 citations

, , +17

Immunologic Factors and Clinical Activity in Systemic Lupus Erythematosus

Peter H. Schur, John Sandson · New England Journal of Medicine · 1968 · 596 citations

, , +17

1–5 of 1.1K

Authors

4.7K

  1. VF
    Véronique Frémeaux‐Bacchi

    Hôpital Européen Georges-Pompidou, France

    39 publications · 6K citations

    34

    h-index

  2. TH
    Timothy H.J. Goodship

    Newcastle University, United Kingdom

    23 publications · 4.5K citations

    21

    h-index

  3. MD
    Marie‐Agnès Dragon‐Durey

    Hôpital Européen Georges-Pompidou, France

    17 publications · 3.4K citations

    16

    h-index

  4. SR
    Santiago Rodrı́guez de Córdoba

    Centro de Investigaciones Biológicas Margarita Salas, Spain

    17 publications · 2.2K citations

    16

    h-index

  5. MW
    Mark Walport

    Hammersmith Hospital, United Kingdom

    16 publications · 1.8K citations

    16

    h-index

1–5 of 4.7K

Institutions

1.3K

  1. Hôpital Européen

    Marseille, France

    28 h-index

    81 publications

    10.7K citations

  2. Hôpital Européen Georges-Pompidou

    Paris, France

    27 h-index

    83 publications

    10.4K citations

  3. Lund University

    Lund, Sweden

    27 h-index

    124 publications

    6K citations

  4. Inserm

    Paris, France

    26 h-index

    121 publications

    14.4K citations

  5. Newcastle University

    Newcastle upon Tyne, United Kingdom

    24 h-index

    93 publications

    13.8K citations

  6. Assistance Publique – Hôpitaux de Paris

    Paris, France

    22 h-index

    94 publications

    16.1K citations

  7. Washington University in St. Louis

    St Louis, United States

    21 h-index

    83 publications

    8.6K citations

  8. Johannes Gutenberg University Mainz

    Mainz, Germany

    20 h-index

    85 publications

    6.3K citations

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Venues

  1. PubMed

    Repository · 173 publications · 6.3K citations

    42

    h-index

  2. The Journal of Immunology

    JI · 53 publications · 3.6K citations

    34

    h-index

  3. Arthritis & Rheumatism

    58 publications · 3.4K citations

    34

    h-index

  4. Journal of Clinical Investigation

    JCI · 41 publications · 3.8K citations

    33

    h-index

  5. New England Journal of Medicine

    NEJM · 21 publications · 3.6K citations

    21

    h-index

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