Concepedia

(Aryloxyacetylamino)benzoic Acid Analogues:  A New Class of Hypoxia-Inducible Factor-1 Inhibitors

Kyeong Lee, Jeong Hyun Lee, Shanthaveerappa K. Boovanahalli, Yinglan Jin, Mijeoung Lee, Xuejun Jin, Jin Hwan Kim, Young‐Soo Hong, Jung Joon Lee

Journal of Medicinal Chemistry · 2007 · 139 citations · 10 references

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Abstract

Structural modification of a compound discovered during screening using an HRE-dependent reporter assay has revealed a novel class of HIF-1 inhibitors, which potently inhibit the HIF-1alpha protein accumulation and its target gene expression under hypoxic conditions in human hepatocellular carcinoma Hep3B cells.

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