Gabi U. Dachs

Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth

Patrick H. Maxwell, Gabi U. Dachs, Jonathan Gleadle et al. · Proceedings of the National Academy of Sciences · 1997 · 1.1K citations · Full text

Angiogenesis, Solid Tumors, Heterodimeric Transcription Factor +15

Targeting gene expression to hypoxic tumor cells

Gabi U. Dachs, Adam V. Patterson, John D. Firth et al. · Nature Medicine · 1997 · 367 citations

Tumor Biology, Redox Regulator, Medicine +5

The Bioreductive Prodrug PR-104A Is Activated under Aerobic Conditions by Human Aldo-Keto Reductase 1C3

Christopher P. Guise, Maria R. Abbattista, Rachelle S. Singleton et al. · Cancer Research · 2010 · 185 citations · Full text

Cancer Metabolism, Reductive Stress, Tumor Hypoxia +15

The influence of oxygen tension and pH on the expression of platelet-derived endothelial cell growth factor/thymidine phosphorylase in human breast tumor cells grown in vitro and in vivo.

Leigh G. Griffiths, Gabi U. Dachs, Roy Bicknell et al. · PubMed · 1997 · 175 citations

Pathology, Cell Proliferation, Tumor Biology +17

Low Ascorbate Levels Are Associated with Increased Hypoxia-Inducible Factor-1 Activity and an Aggressive Tumor Phenotype in Endometrial Cancer

Caroline Kuiper, Ilona G.M. Molenaar, Gabi U. Dachs et al. · Cancer Research · 2010 · 134 citations · Full text

Tumor Biology, Ascorbate Content, Aggressive Tumor Phenotype +15