Adam V. Patterson

Targeting gene expression to hypoxic tumor cells

Gabi U. Dachs, Adam V. Patterson, John D. Firth et al. · Nature Medicine · 1997 · 367 citations

Tumor Biology, Redox Regulator, Medicine +5

Glucose transporter glut-1 expression correlates with tumor hypoxia and predicts metastasis-free survival in advanced carcinoma of the cervix.

Rachel Airley, J. Loncaster, S.E. Davidson et al. · PubMed · 2001 · 326 citations

Pathology, Metastasis-free Survival, Cancer Biology +17

Mechanism of Action and Preclinical Antitumor Activity of the Novel Hypoxia-Activated DNA Cross-Linking Agent PR-104

Adam V. Patterson, Dianne M. Ferry, Shelley J. Edmunds et al. · Clinical Cancer Research · 2007 · 243 citations · Full text

Molecular and Cellular Pharmacology of the Hypoxia-Activated Prodrug TH-302

Fanying Meng, James Evans, Deepthi Bhupathi et al. · Molecular Cancer Therapeutics · 2011 · 203 citations

Pharmacotherapy, Redox Biology, Oxidative Stress +18

The Bioreductive Prodrug PR-104A Is Activated under Aerobic Conditions by Human Aldo-Keto Reductase 1C3

Christopher P. Guise, Maria R. Abbattista, Rachelle S. Singleton et al. · Cancer Research · 2010 · 185 citations · Full text

Cancer Metabolism, Reductive Stress, Tumor Hypoxia +15