Adam V. Patterson

Targeting gene expression to hypoxic tumor cells

Gabi U. Dachs, Adam V. Patterson, John D. Firth et al. · Nature Medicine · 1997 · 368 citations

Medicine, Cancer Biology, Oncology +14

Glucose transporter glut-1 expression correlates with tumor hypoxia and predicts metastasis-free survival in advanced carcinoma of the cervix.

Rachel Airley, J. Loncaster, S.E. Davidson et al. · PubMed · 2001 · 326 citations · Full text

Medicine, Cancer Biology, Oncology +17

Mechanism of Action and Preclinical Antitumor Activity of the Novel Hypoxia-Activated DNA Cross-Linking Agent PR-104

Adam V. Patterson, Dianne M. Ferry, Shelley J. Edmunds et al. · Clinical Cancer Research · 2007 · 247 citations · Full text

Medicine, Oncology, Pharmacology +16

Molecular and Cellular Pharmacology of the Hypoxia-Activated Prodrug TH-302

Fanying Meng, James Evans, Deepthi Bhupathi et al. · Molecular Cancer Therapeutics · 2011 · 206 citations

Medicine, Medicinal Chemistry, Pharmacology +17

The Bioreductive Prodrug PR-104A Is Activated under Aerobic Conditions by Human Aldo-Keto Reductase 1C3

Christopher P. Guise, Maria R. Abbattista, Rachelle S. Singleton et al. · Cancer Research · 2010 · 187 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17