Concepedia

Targeting gene expression to hypoxic tumor cells

Gabi U. Dachs, Adam V. Patterson, John D. Firth, Peter J. Ratcliffe, K. M. S. Townsend, Ian J. Stratford, Adrian L. Harris

Nature Medicine · 1997 · 368 citations · 22 references

DOI

Concepts

References

22

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.

G L Wang, Bing‐Hua Jiang, E A Rue et al. · Proceedings of the National Academy of Sciences · 1995 · 6.2K citations

, , +17

Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis

Dorit Shweiki, Ahuva Itin, Dov Soffer et al. · Nature · 1992 · 4.6K citations

, , +11

General involvement of hypoxia-inducible factor 1 in transcriptional response to hypoxia.

G L Wang, Gregg L. Semenza · Proceedings of the National Academy of Sciences · 1993 · 1.5K citations

, , +17

Transcriptional Regulation of the Rat Vascular Endothelial Growth Factor Gene by Hypoxia

Andrew P. Levy, Nina S. Levy, Scott A. Wegner et al. · Journal of Biological Chemistry · 1995 · 1.1K citations · Full text

, , +15

Complementation by the protein tyrosine kinase JAK2 of a mutant cell line defective in the interferon-& gamma; signal transduction pathway

Diane Watling, Dmitry Guschin, Mathias Müller et al. · Nature · 1993 · 544 citations

, , +16