Concepedia

2ME2 inhibits tumor growth and angiogenesis by disrupting microtubules and dysregulating HIF

Nicola J. Mabjeesh, Daniel Escuín, Theresa LaVallee, Victor S. Pribluda, Glenn M. Swartz, Michelle S. Johnson, Margaret Willard, Hua Zhong, Jonathan W. Simons, Paraskevi Giannakakou

Cancer Cell · 2003 · 726 citations · 59 references

DOI

Concepts

References

59

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.

G L Wang, Bing‐Hua Jiang, E A Rue et al. · Proceedings of the National Academy of Sciences · 1995 · 6.2K citations

, , +17

Tumor Angiogenesis and Metastasis — Correlation in Invasive Breast Carcinoma

Noel Weidner, Joseph P. Semple, William R. Welch et al. · New England Journal of Medicine · 1991 · 5.7K citations

, , +15

Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O <sub>2</sub> -Regulated Prolyl Hydroxylation

Panu Jaakkola, David R. Mole, Ya‐Min Tian et al. · Science · 2001 · 5.5K citations

, , +17

HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O <sub>2</sub> Sensing

Mircea Ivan, Keiichi Kondo, Haifeng Yang et al. · Science · 2001 · 4.7K citations · Full text

, , +16

Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis

Dorit Shweiki, Ahuva Itin, Dov Soffer et al. · Nature · 1992 · 4.6K citations

, , +11