Paraskevi Giannakakou

Identification of distinct nanoparticles and subsets of extracellular vesicles by asymmetric flow field-flow fractionation

Haiying Zhang, Daniela Freitas, Han Sang Kim et al. · Nature Cell Biology · 2018 · 1.6K citations · Full text

Life Sciences, Biophysics, Cell Biology +13

2ME2 inhibits tumor growth and angiogenesis by disrupting microtubules and dysregulating HIF

Nicola J. Mabjeesh, Daniel Escuín, Theresa LaVallee et al. · Cancer Cell · 2003 · 726 citations

Medicine, Cancer Biology, Oncology +12

Paclitaxel-resistant Human Ovarian Cancer Cells Have Mutant β-Tubulins That Exhibit Impaired Paclitaxel-driven Polymerization

Paraskevi Giannakakou, Dan L. Sackett, Yoon‐Koo Kang et al. · Journal of Biological Chemistry · 1997 · 682 citations · Full text

Medicine, Oncology, Pharmacology +12

Activities of the Microtubule-stabilizing Agents Epothilones A and B with Purified Tubulin and in Cells Resistant to Paclitaxel (Taxol®)

Richard Kowalski, Paraskevi Giannakakou, Ernest Hamel · Journal of Biological Chemistry · 1997 · 512 citations · Full text

Medicine, Pharmacology, Chemotherapy +8

A common pharmacophore for epothilone and taxanes: Molecular basis for drug resistance conferred by tubulin mutations in human cancer cells

Paraskevi Giannakakou, Rick Gussio, Eva Nogales et al. · Proceedings of the National Academy of Sciences · 2000 · 477 citations

Medicine, Medicinal Chemistry, Pharmacology +15