Identification of distinct nanoparticles and subsets of extracellular vesicles by asymmetric flow field-flow fractionation

Haiying Zhang, Daniela Freitas, Han Sang Kim, +39

Nature Cell Biology

NanoparticlesExtracellular VesiclesEngineeringMedicineField-flow Fractionation +9

2ME2 inhibits tumor growth and angiogenesis by disrupting microtubules and dysregulating HIF

Nicola J. Mabjeesh, Daniel Escuín, Theresa LaVallee, +7

Cancer Cell

Tumor BiologyAngiogenesisMedicineVascular BiologyInhibits Tumor Growth +7

Paclitaxel-resistant Human Ovarian Cancer Cells Have Mutant β-Tubulins That Exhibit Impaired Paclitaxel-driven Polymerization

Paraskevi Giannakakou, Dan L. Sackett, Yoon‐Koo Kang, +4

Journal of Biological Chemistry

Activities of the Microtubule-stabilizing Agents Epothilones A and B with Purified Tubulin and in Cells Resistant to Paclitaxel (Taxol®)

Richard Kowalski, Paraskevi Giannakakou, Ernest Hamel

Journal of Biological Chemistry

A common pharmacophore for epothilone and taxanes: Molecular basis for drug resistance conferred by tubulin mutations in human cancer cells

Paraskevi Giannakakou, Rick Gussio, Eva Nogales, +7

Proceedings of the National Academy of Sciences

Tubulin BindingDrug TargetMolecular BiologyTubulin Mutant CellsChemical Biology +17

Taxane-Induced Blockade to Nuclear Accumulation of the Androgen Receptor Predicts Clinical Responses in Metastatic Prostate Cancer

Medha S. Darshan, Matthew S. Loftus, Maria Thadani‐Mulero, +10

Cancer Research

Cancer BiologyTumor BiologyMetastatic Prostate CancerGenitourinary CancerCancer Cell Biology +16

Capture of circulating tumor cells from whole blood of prostate cancer patients using geometrically enhanced differential immunocapture (GEDI) and a prostate-specific antibody

Jason P. Gleghorn, Erica D. Pratt, Denise Denning, +6

Lab on a Chip

Immunocytochemical TechniqueProstate Cancer PatientsImmunologyBlood CellImmunophenotyping +14

Raf-1/bcl-2 phosphorylation: a step from microtubule damage to cell death.

Mikhail V. Blagosklonny, Paraskevi Giannakakou, Wafik S. El‐Deiry, +4

PubMed

Chemoprevention StrategyApoptosisMolecular BiologyCell DeathCytoskeleton +19

p53 is associated with cellular microtubules and is transported to the nucleus by dynein

Paraskevi Giannakakou, Dan L. Sackett, Yvona Ward, +3

Nature Cell Biology

Cellular MicrotubulesNatural SciencesCell InteractionMolecular BiologyCell Motility +5

Microtubule-interfering Agents Activate c-Jun N-terminal Kinase/Stress-activated Protein Kinase through Both Ras and Apoptosis Signal-regulating Kinase Pathways

Tzu‐Hao Wang, Hsin-Shih Wang, Hidenori Ichijo, +4

Journal of Biological Chemistry