Rick Gussio

A common pharmacophore for epothilone and taxanes: Molecular basis for drug resistance conferred by tubulin mutations in human cancer cells

Paraskevi Giannakakou, Rick Gussio, Eva Nogales et al. · Proceedings of the National Academy of Sciences · 2000 · 475 citations

Tubulin Binding, Drug Target, Molecular Biology +19

Paullones are potent inhibitors of glycogen synthase kinase‐3β and cyclin‐dependent kinase 5/p25

Maryse Leost, Christiane Schultz, Andreas Link et al. · European Journal of Biochemistry · 2000 · 370 citations · Full text

Paullones, a Series of Cyclin-Dependent Kinase Inhibitors:  Synthesis, Evaluation of CDK1/Cyclin B Inhibition, and in Vitro Antitumor Activity

Christiane Schultz, Andreas Link, Maryse Leost et al. · Journal of Medicinal Chemistry · 1999 · 326 citations · Full text

A Common Pharmacophore for a Diverse Set of Colchicine Site Inhibitors Using a Structure-Based Approach

Tam Luong Nguyen, Connor F. McGrath, Ann Hermone et al. · Journal of Medicinal Chemistry · 2005 · 286 citations

Drug Target, Protein Assembly, Molecular Biology +22

Discovery and initial characterization of the paullones, a novel class of small-molecule inhibitors of cyclin-dependent kinases.

Daniel Zaharevitz, Rick Gussio, Maryse Leost et al. · PubMed · 1999 · 226 citations

Drug Target, Chemoprevention Strategy, Pathology +21