Indirubin, the active constituent of a Chinese antileukaemia medicine, inhibits cyclin-dependent kinases

Ralph Hoessel, Sophie Leclerc, Jane Endicott, +11

Nature Cell Biology

Hematological MalignancyCyclin-dependent KinasesChinese Antileukaemia MedicineActive ConstituentMedicine +5

GSK-3-Selective Inhibitors Derived from Tyrian Purple Indirubins

Laurent Meijer, Alexios-Leandros Skaltsounis, Prokopios Magiatis, +12

Chemistry & Biology

Molecular PharmacologyMedicinal ChemistryGsk-3-selective InhibitorsMedicineAnti-cancer Agent +4

Structural Basis for the Synthesis of Indirubins as Potent and Selective Inhibitors of Glycogen Synthase Kinase-3 and Cyclin-Dependent Kinases

Panagiotis Polychronopoulos, Prokopios Magiatis, Alexios‐Léandros Skaltsounis, +8

Journal of Medicinal Chemistry

Paullones, a Series of Cyclin-Dependent Kinase Inhibitors:  Synthesis, Evaluation of CDK1/Cyclin B Inhibition, and in Vitro Antitumor Activity

Christiane Schultz, Andreas Link, Maryse Leost, +5

Journal of Medicinal Chemistry

Synthesis and application of functionally diverse 2,6,9-trisubstituted purine libraries as CDK inhibitors

Young‐Tae Chang, Nathanael S. Gray, Gustavo R. Rosania, +7

Chemistry & Biology

Combinatorial ChemistryCdk InhibitorsBiochemistryMedicinePharmacological Agent +3

Discovery and initial characterization of the paullones, a novel class of small-molecule inhibitors of cyclin-dependent kinases.

Daniel Zaharevitz, Rick Gussio, Maryse Leost, +5

PubMed

Drug TargetChemoprevention StrategyPathologyPharmacotherapyTumor Biology +19

Meridianins, a new family of protein kinase inhibitors isolated from the Ascidian Aplidium meridianum

Marie Gompel, Maryse Leost, Elisa Bal de Kier Joffé, +4

Bioorganic & Medicinal Chemistry Letters

New FamilyNatural SciencesMedicineReceptor Tyrosine KinaseProtein Kinase Inhibitors +7

1-Azakenpaullone is a selective inhibitor of glycogen synthase kinase-3β

Conrad Kunick, Kathrin Lauenroth, Maryse Leost, +2

Bioorganic & Medicinal Chemistry Letters

Molecular PharmacologyMedicinal ChemistryGlycogen Synthase Kinase-3βMedicineCell Biology +3

Aloisines, a New Family of CDK/GSK-3 Inhibitors. SAR Study, Crystal Structure in Complex with CDK2, Enzyme Selectivity, and Cellular Effects

Yvette Mettey, Marie Gompel, Virginie Thomas, +7

Journal of Medicinal Chemistry

Intracellular Targets of Paullones

Marie Knockaert, Karen Wieking, Sophie Schmitt, +5

Journal of Biological Chemistry

Medicinal ChemistryIntracellular TargetsBiochemistryMitochondrial FunctionMedicine +13