Synthesis and application of functionally diverse 2,6,9-trisubstituted purine libraries as CDK inhibitors

Re-examination and further development of a precise and rapid dye method for measuring cell growth/cell kill

Morten Hansen, Svend Erik Nielsen, Kurt Berg · Journal of Immunological Methods · 1989 · 3.5K citations

Life Sciences, Cell Biology, Cell Proliferation +11

Biochemical and Cellular Effects of Roscovitine, a Potent and Selective Inhibitor of the Cyclin‐Dependent Kinases cdc2, cdk2 and cdk5

Laurent Meijer, Annie Borgne, Odile Mulner et al. · European Journal of Biochemistry · 1997 · 1.4K citations

Medicine, Cancer Biology, Oncology +15

Exploiting Chemical Libraries, Structure, and Genomics in the Search for Kinase Inhibitors

Nathanael S. Gray, Lisa Wodicka, A.M.W.H. Thunnissen et al. · Science · 1998 · 808 citations · Full text

Pharmacy, Medicinal Chemistry, Molecular Biology +15

Inhibition of Cyclin‐Dependent Kinases by Purine Analogues

Jaroslav Veselý, Libor Havlı́ček, Miroslav Strnad et al. · European Journal of Biochemistry · 1994 · 626 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +16

Structural basis for specificity and potency of a flavonoid inhibitor of human CDK2, a cell cycle kinase.

Walter Filgueira de Azevedo, H J Mueller-Dieckmann, Ursula Schulze‐Gahmen et al. · Proceedings of the National Academy of Sciences · 1996 · 500 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +14