Concepedia

Indirubin, the active constituent of a Chinese antileukaemia medicine, inhibits cyclin-dependent kinases

Ralph Hoessel, Sophie Leclerc, Jane Endicott, Martin E. M. Nobel, Alison M. Lawrie, Paul Tunnah, Maryse Leost, Eve Damiens, Dominique Marie, Doris Marko,

Nature Cell Biology · 1999 · 814 citations · 23 references

DOI

Concepts

References

23

The CCP4 suite: programs for protein crystallography

Number Collaborative Computational Project · Acta Crystallographica Section D Biological Crystallography · 1994 · 17.3K citations

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Biochemical and Cellular Effects of Roscovitine, a Potent and Selective Inhibitor of the Cyclin‐Dependent Kinases cdc2, cdk2 and cdk5

Laurent Meijer, Annie Borgne, Odile Mulner et al. · European Journal of Biochemistry · 1997 · 1.4K citations

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Crystal structure of cyclin-dependent kinase 2

Hendrik L. De Bondt, Jody Rosenblatt, Jarmila Jancarik et al. · Nature · 1993 · 968 citations

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Structure of a Peptide Inhibitor Bound to the Catalytic Subunit of Cyclic Adenosine Monophosphate-Dependent Protein Kinase

Daniel R. Knighton, Jianhua Zheng, Lynn F. Ten Eyck et al. · Science · 1991 · 963 citations

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Exploiting Chemical Libraries, Structure, and Genomics in the Search for Kinase Inhibitors

Nathanael S. Gray, Lisa Wodicka, A.M.W.H. Thunnissen et al. · Science · 1998 · 808 citations · Full text

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