Concepedia

Author

Ernest Hamel

National Cancer InstituteORCID

Also Known As

BRANCALE A., E Hamel, E. HAMEL, E. Hamel, E.G. Hamel, ERNEST HAMEL, Ernest HAMEL, Ernest Hamel, Goto, Masuo, Hamel, E.

658

Publications

29.1K

Citations

86

H-Index

124

Concepts

All Affiliations

National Cancer InstituteNational Institutes of HealthFrederick National Laboratory for Cancer ResearchUniversity of PaduaUniversity of Ferrara
EH

About

Ernest Hamel is an author at National Cancer Institute specializing in medicine, pharmacology, and drug discovery.

Top Concepts

#ConceptH-IndexPublicationsCitations

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Medicine

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Natural Sciences

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Engineering

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Health Sciences

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Social Sciences

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Ernest Hamel

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382

Publications

27.4K

Citations

85

H-Index

YearCitations

Isolation and structure of the strong cell growth and tubulin inhibitor combretastatin A-4

George R. Pettit, Sheo B. Singh, Ernest Hamel,

Cellular and Molecular Life Sciences

1989

783

Activities of the Microtubule-stabilizing Agents Epothilones A and B with Purified Tubulin and in Cells Resistant to Paclitaxel (Taxol®)

Richard Kowalski, Paraskevi Giannakakou, Ernest Hamel

Journal of Biological Chemistry

1997

512

Antimitotic natural products combretastatin A-4 and combretastatin A-2: studies on the mechanism of their inhibition of the binding of colchicine to tubulin

Chii M. Lin, Holly H. Ho, George R. Pettit,

Biochemistry

1989

412

2-Methoxyestradiol, an endogenous mammalian metabolite, inhibits tubulin polymerization by interacting at the colchicine site.

Robert J. D’Amato, C. Michael Lin, Evelyn Flynn,

Proceedings of the National Academy of Sciences

1994

407

6-Alkylamino- and 2,3-Dihydro-3‘-methoxy-2-phenyl-4-quinazolinones and Related Compounds:  Their Synthesis, Cytotoxicity, and Inhibition of Tubulin Polymerization

Mann‐Jen Hour, Li‐Jiau Huang, Sheng‐Chu Kuo,

Journal of Medicinal Chemistry

2000

404

Synthesis of epothilones A and B in solid and solution phase

K. C. Nicolaou, Nicolas Winssinger, Joaquı́n Pastor,

Nature

1997

398

Antineoplastic Agents. 291. Isolation and Synthesis of Combretastatins A-4, A-5, and A-6

George R. Pettit, Sheo B. Singh, Michael R. Boyd,

Journal of Medicinal Chemistry

1995

389

Discodermolide, A Cytotoxic Marine Agent That Stabilizes Microtubules More Potently Than Taxol<sup>,</sup>

Ernst ter Haar, Richard Kowalski, Ernest Hamel,

Biochemistry

1996

381

Halichondrin B and homohalichondrin B, marine natural products binding in the vinca domain of tubulin. Discovery of tubulin-based mechanism of action by analysis of differential cytotoxicity data

Ruo Li Bai, Kenneth D. Paull, Cherry L. Herald,

Journal of Biological Chemistry

1991

375

Requirement of an Escherichia coli 50 S Ribosomal Protein Component for Effective Interaction of the Ribosome with T and G Factors and with Guanosine Triphosphate

Ernest Hamel, M. Koka, Tokumasa Nakamoto

Journal of Biological Chemistry

1972

362

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