Ernest Hamel

Isolation and structure of the strong cell growth and tubulin inhibitor combretastatin A-4

George R. Pettit, Sheo B. Singh, Ernest Hamel et al. · Cellular and Molecular Life Sciences · 1989 · 783 citations

Natural Sciences, Molecular Biology, Cytoskeleton +8

Activities of the Microtubule-stabilizing Agents Epothilones A and B with Purified Tubulin and in Cells Resistant to Paclitaxel (Taxol®)

Richard Kowalski, Paraskevi Giannakakou, Ernest Hamel · Journal of Biological Chemistry · 1997 · 512 citations · Full text

Antimitotic natural products combretastatin A-4 and combretastatin A-2: studies on the mechanism of their inhibition of the binding of colchicine to tubulin

Chii M. Lin, Holly H. Ho, George R. Pettit et al. · Biochemistry · 1989 · 412 citations

Chromatin, Medicinal Chemistry, Molecular Pharmacology +15

2-Methoxyestradiol, an endogenous mammalian metabolite, inhibits tubulin polymerization by interacting at the colchicine site.

Robert J. D’Amato, C. Michael Lin, Evelyn Flynn et al. · Proceedings of the National Academy of Sciences · 1994 · 407 citations · Full text

Molecular Pharmacology, Tubulin Assembly, Biochemistry +15

6-Alkylamino- and 2,3-Dihydro-3‘-methoxy-2-phenyl-4-quinazolinones and Related Compounds:  Their Synthesis, Cytotoxicity, and Inhibition of Tubulin Polymerization

Mann‐Jen Hour, Li‐Jiau Huang, Sheng‐Chu Kuo et al. · Journal of Medicinal Chemistry · 2000 · 404 citations · Full text

Pharmaceutical Science, Chemoprevention Strategy, Organic Chemistry +18