Ernest Hamel

Isolation and structure of the strong cell growth and tubulin inhibitor combretastatin A-4

George R. Pettit, Sheo B. Singh, Ernest Hamel et al. · Cellular and Molecular Life Sciences · 1989 · 789 citations

Life Sciences, Biochemistry, Cell Biology +11

Activities of the Microtubule-stabilizing Agents Epothilones A and B with Purified Tubulin and in Cells Resistant to Paclitaxel (Taxol®)

Richard Kowalski, Paraskevi Giannakakou, Ernest Hamel · Journal of Biological Chemistry · 1997 · 512 citations · Full text

Medicine, Pharmacology, Chemotherapy +8

Antimitotic natural products combretastatin A-4 and combretastatin A-2: studies on the mechanism of their inhibition of the binding of colchicine to tubulin

Chii M. Lin, Holly H. Ho, George R. Pettit et al. · Biochemistry · 1989 · 414 citations

Medicine, Medicinal Chemistry, Pharmacology +17

2-Methoxyestradiol, an endogenous mammalian metabolite, inhibits tubulin polymerization by interacting at the colchicine site.

Robert J. D’Amato, C. Michael Lin, Evelyn Flynn et al. · Proceedings of the National Academy of Sciences · 1994 · 409 citations

Life Sciences, Chemical Biology, Pharmacology +16

6-Alkylamino- and 2,3-Dihydro-3‘-methoxy-2-phenyl-4-quinazolinones and Related Compounds:  Their Synthesis, Cytotoxicity, and Inhibition of Tubulin Polymerization

Mann‐Jen Hour, Li‐Jiau Huang, Sheng‐Chu Kuo et al. · Journal of Medicinal Chemistry · 2000 · 407 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +10