A metabolite of daidzein, 6,7,4′‐trihydroxyisoflavone, suppresses adipogenesis in 3<scp>T</scp>3‐<scp>L</scp>1 preadipocytes via <scp>ATP</scp>‐competitive inhibition of <scp>PI</scp>3<scp>K</scp>

Abstract

Our results suggest that 6,7,4'-THIF suppresses adipogenesis in 3T3-L1 preadipocytes by directly targeting PI3K. Soy isoflavones like 6,7,4'-THIF may have potential for development into novel treatment strategies for chronic obesity.