Concepedia

Cyclooxygenase-2 Regulates Th17 Cell Differentiation during Allergic Lung Inflammation

Hong Li, J. Alyce Bradbury, Ryan T. Dackor, Matthew L. Edin, Joan P. Graves, Laura M. DeGraff, Ping Ming Wang, Carl D. Bortner, Shuichiro Maruoka, Fred B. Lih,

American Journal of Respiratory and Critical Care Medicine · 2011 · 66 citations · 39 references

DOIFull text

Open access

Abstract

COX-2 is a critical regulator of Th17 cell differentiation during allergic lung inflammation via autocrine signaling of PGI(2) and PGF(2α) through their respective cell surface receptors.

References

39

The Orphan Nuclear Receptor RORγt Directs the Differentiation Program of Proinflammatory IL-17+ T Helper Cells

Ivaylo I. Ivanov, Brent S. McKenzie, Liang Zhou et al. · Cell · 2006 · 5K citations · Full text

, , +9

Phenotypic and functional features of human Th17 cells

Francesco Annunziato, Lorenzo Cosmi, Veronica Santarlasci et al. · The Journal of Experimental Medicine · 2007 · 1.8K citations · Full text

Human TH17 lymphocytes promote blood-brain barrier disruption and central nervous system inflammation

Hania Kébir, Katharina Kreymborg, Igal Ifergan et al. · Nature Medicine · 2007 · 1.7K citations · Full text

, , +12

The differentiation of human TH-17 cells requires transforming growth factor-β and induction of the nuclear receptor RORγt

Nicolas Manel, Derya Unutmaz, Dan R. Littman · Nature Immunology · 2008 · 1.3K citations · Full text

, , +8

Inducible cyclooxygenase may have anti-inflammatory properties

Derek W. Gilroy, Paul Colville‐Nash, Dean Willis et al. · Nature Medicine · 1999 · 1.2K citations

, , +9