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Sulfonyl-morpholino-pyrimidines: SAR and development of a novel class of selective mTOR kinase inhibitor

M. Raymond V. Finlay, David Buttar, Susan E. Critchlow, Allan Dishington, Shaun Fillery, Eric F. Fisher, Steve Glossop, M. A. Graham, Trevor Johnson, Gillian M. Lamont,

Bioorganic & Medicinal Chemistry Letters · 2012 · 33 citations · 8 references

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8

Structural Determinants of Phosphoinositide 3-Kinase Inhibition by Wortmannin, LY294002, Quercetin, Myricetin, and Staurosporine

Edward H. Walker, Michael E. Pacold, Olga Perišić et al. · Molecular Cell · 2000 · 1.2K citations · Full text

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Structural insights into phosphoinositide 3-kinase catalysis and signalling

Edward H. Walker, Olga Perišić, Christian Ried et al. · Nature · 1999 · 493 citations

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Heteroaromatic Thioether−Boronic Acid Cross-Coupling under Neutral Reaction Conditions

Lanny S. Liebeskind, Jiří Šrogl · Organic Letters · 2002 · 275 citations

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Morpholine Derivatives Greatly Enhance the Selectivity of Mammalian Target of Rapamycin (mTOR) Inhibitors

Arie Zask, Joshua A. Kaplan, Jeroen C. Verheijen et al. · Journal of Medicinal Chemistry · 2009 · 97 citations · Full text

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The discovery and optimisation of pyrido[2,3-d]pyrimidine-2,4-diamines as potent and selective inhibitors of mTOR kinase

Karine Malagu, Heather M. E. Duggan, Keith Menear et al. · Bioorganic & Medicinal Chemistry Letters · 2009 · 80 citations · Full text

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