Shaun Fillery

Discovery of 4-{4-[(3<i>R</i>)-3-Methylmorpholin-4-yl]-6-[1-(methylsulfonyl)cyclopropyl]pyrimidin-2-yl}-1<i>H</i>-indole (AZ20): A Potent and Selective Inhibitor of ATR Protein Kinase with Monotherapy in Vivo Antitumor Activity

Kevin M. Foote, Kevin Blades, Anna Cronin et al. · Journal of Medicinal Chemistry · 2013 · 213 citations · Full text

Compound 6, Pharmacotherapy, Pharmaceutical Chemistry +17

Potent and Selective Inhibitors of MTH1 Probe Its Role in Cancer Cell Survival

Jason G. Kettle, Husam Alwan, Michał Biśta et al. · Journal of Medicinal Chemistry · 2016 · 135 citations · Full text

Tool Compounds, Chemoprevention Strategy, Selective Inhibitors +18

Development of a Novel B-Cell Lymphoma 6 (BCL6) PROTAC To Provide Insight into Small Molecule Targeting of BCL6

William McCoull, Tony Cheung, Erica Anderson et al. · ACS Chemical Biology · 2018 · 133 citations · Full text

Hematological Malignancy, Lymphoid Neoplasia, B-cell Lymphoma 6 +14

Structure-Based Design and Pharmacokinetic Optimization of Covalent Allosteric Inhibitors of the Mutant GTPase KRAS^G12C

Jason G. Kettle, Sharan K. Bagal, Sue Bickerton et al. · Journal of Medicinal Chemistry · 2020 · 80 citations · Full text

Discovery of Pyrazolo[1,5-<i>a</i>]pyrimidine B-Cell Lymphoma 6 (BCL6) Binders and Optimization to High Affinity Macrocyclic Inhibitors

William McCoull, Roman Abrams, Erica Anderson et al. · Journal of Medicinal Chemistry · 2017 · 78 citations · Full text