Steve Glossop

Discovery of AZD4573, a Potent and Selective Inhibitor of CDK9 That Enables Short Duration of Target Engagement for the Treatment of Hematological Malignancies

Bernard Barlaam, Robert Casella, Justin Cidado et al. · Journal of Medicinal Chemistry · 2020 · 104 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +15

Optimization of a Series of Bivalent Triazolopyridazine Based Bromodomain and Extraterminal Inhibitors: The Discovery of (3<i>R</i>)-4-[2-[4-[1-(3-Methoxy-[1,2,4]triazolo[4,3-<i>b</i>]pyridazin-6-yl)-4-piperidyl]phenoxy]ethyl]-1,3-dimethyl-piperazin-2-one (AZD5153)

Robert H. Bradbury, Rowena Callis, Gregory R. Carr et al. · Journal of Medicinal Chemistry · 2016 · 86 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +15

Sulfonyl-morpholino-pyrimidines: SAR and development of a novel class of selective mTOR kinase inhibitor

M. Raymond V. Finlay, David Buttar, Susan E. Critchlow et al. · Bioorganic & Medicinal Chemistry Letters · 2012 · 33 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +11

Discovery and Optimization of a Novel Series of Potent Mutant B-Raf^V600E Selective Kinase Inhibitors

Melissa M. Vasbinder, Brian Aquila, Martin Augustin et al. · Journal of Medicinal Chemistry · 2013 · 31 citations · Full text

Medicine, Oncology, Pharmacology +13