Joshua A. Kaplan

<i>Ex Vivo</i> Profiling of PD-1 Blockade Using Organotypic Tumor Spheroids

Russell W. Jenkins, Amir Reza Aref, Patrick H. Lizotte et al. · Cancer Discovery · 2017 · 585 citations

Medicine, Immunology, Oncology +17

Beyond Rapalog Therapy: Preclinical Pharmacology and Antitumor Activity of WYE-125132, an ATP-Competitive and Specific Inhibitor of mTORC1 and mTORC2

Ker Yu, Celine Shi, Lourdes Toral‐Barza et al. · Cancer Research · 2010 · 208 citations · Full text

Medicine, Oncology, Pharmacology +14

A structural and dynamic model for the assembly of Replication Protein A on single-stranded DNA

Luke A. Yates, Ricardo Aramayo, Nilisha Pokhrel et al. · Nature Communications · 2018 · 155 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

ATP-Competitive Inhibitors of the Mammalian Target of Rapamycin: Design and Synthesis of Highly Potent and Selective Pyrazolopyrimidines

Arie Zask, Jeroen C. Verheijen, Kevin J. Curran et al. · Journal of Medicinal Chemistry · 2009 · 98 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +15

Morpholine Derivatives Greatly Enhance the Selectivity of Mammalian Target of Rapamycin (mTOR) Inhibitors

Arie Zask, Joshua A. Kaplan, Jeroen C. Verheijen et al. · Journal of Medicinal Chemistry · 2009 · 97 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17