Discovery of novel imidazo[1,2-a]pyridines as inhibitors of the insulin-like growth factor-1 receptor tyrosine kinase

Poly(ethylene glycol) (PEG) as a Reusable Solvent Medium for Organic Synthesis. Application in the Heck Reaction

S. Chandrasekhar, Ch. Narsihmulu, S. Shameem Sultana et al. · Organic Letters · 2002 · 313 citations

Ethylene Glycol, Regioselective Heck Reactions, Engineering +17

Discovery of OSI-906: A Selective and Orally Efficacious Dual Inhibitor of the IGF-1 Receptor and Insulin Receptor

Mark J. Mulvihill, Andrew Cooke, Maryland Rosenfeld-Franklin et al. · Future Medicinal Chemistry · 2009 · 307 citations · Full text

Antitumor Activity of the Insulin-Like Growth Factor-I Receptor Kinase Inhibitor NVP-AEW541 in Musculoskeletal Tumors

Katia Scotlandi, Maria Cristina Manara, Giordano Nicoletti et al. · Cancer Research · 2005 · 295 citations

Phase II Study of the Anti–Insulin-Like Growth Factor Type 1 Receptor Antibody CP-751,871 in Combination With Paclitaxel and Carboplatin in Previously Untreated, Locally Advanced, or Metastatic Non–Small-Cell Lung Cancer

Daniel D. Karp, Luis Paz‐Ares, Silvia Novello et al. · Journal of Clinical Oncology · 2009 · 262 citations · Full text

Discovery of a 1<i>H</i>-Benzoimidazol-2-yl)-1<i>H</i>-pyridin-2-one (BMS-536924) Inhibitor of Insulin-like Growth Factor I Receptor Kinase with in Vivo Antitumor Activity

Mark D. Wittman, Joan M. Carboni, Ricardo M. Attar et al. · Journal of Medicinal Chemistry · 2005 · 134 citations · Full text

Pharmacotherapy, Insulin Receptor, Insulin Signaling +21