Lara Ward

Inhibition of PI3Kβ Signaling with AZD8186 Inhibits Growth of PTEN-Deficient Breast and Prostate Tumors Alone and in Combination with Docetaxel

Urs J. Hancox, Sabina Cosulich, Lyndsey Hanson et al. · Molecular Cancer Therapeutics · 2014 · 99 citations · Full text

Medicine, Oncology, Pharmacology +13

Discovery of (<i>R</i>)-8-(1-(3,5-Difluorophenylamino)ethyl)-<i>N</i>,<i>N</i>-dimethyl-2-morpholino-4-oxo-4<i>H</i>-chromene-6-carboxamide (AZD8186): A Potent and Selective Inhibitor of PI3Kβ and PI3Kδ for the Treatment of PTEN-Deficient Cancers

Bernard Barlaam, Sabina Cosulich, Sébastien L. Degorce et al. · Journal of Medicinal Chemistry · 2014 · 87 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +13

Optimization of a Series of Bivalent Triazolopyridazine Based Bromodomain and Extraterminal Inhibitors: The Discovery of (3<i>R</i>)-4-[2-[4-[1-(3-Methoxy-[1,2,4]triazolo[4,3-<i>b</i>]pyridazin-6-yl)-4-piperidyl]phenoxy]ethyl]-1,3-dimethyl-piperazin-2-one (AZD5153)

Robert H. Bradbury, Rowena Callis, Gregory R. Carr et al. · Journal of Medicinal Chemistry · 2016 · 86 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +15

Discovery of novel imidazo[1,2-a]pyridines as inhibitors of the insulin-like growth factor-1 receptor tyrosine kinase

Richard Ducray, Iain Simpson, Frédéric Jung et al. · Bioorganic & Medicinal Chemistry Letters · 2011 · 48 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +8

Biophysical Methods in Drug Discovery from Small Molecule to Pharmaceutical

Geoffrey A. Holdgate, Stefan Geschwindner, Alexander L. Breeze et al. · Methods in molecular biology · 2013 · 44 citations

Pharmacy, Biophysics, Pharmacology +16