Urs J. Hancox

Feedback Suppression of PI3Kα Signaling in PTEN-Mutated Tumors Is Relieved by Selective Inhibition of PI3Kβ

Sarit Schwartz, John Wongvipat, Cath Trigwell et al. · Cancer Cell · 2014 · 261 citations · Full text

Signal Transduction, Signaling Pathway, Cell Regulation +12

Inhibition of PI3Kβ Signaling with AZD8186 Inhibits Growth of PTEN-Deficient Breast and Prostate Tumors Alone and in Combination with Docetaxel

Urs J. Hancox, Sabina Cosulich, Lyndsey Hanson et al. · Molecular Cancer Therapeutics · 2014 · 99 citations · Full text

Discovery of (<i>R</i>)-8-(1-(3,5-Difluorophenylamino)ethyl)-<i>N</i>,<i>N</i>-dimethyl-2-morpholino-4-oxo-4<i>H</i>-chromene-6-carboxamide (AZD8186): A Potent and Selective Inhibitor of PI3Kβ and PI3Kδ for the Treatment of PTEN-Deficient Cancers

Bernard Barlaam, Sabina Cosulich, Sébastien L. Degorce et al. · Journal of Medicinal Chemistry · 2014 · 85 citations · Full text

Pten Deficient Tumors, Pharmacotherapy, Pharmaceutical Chemistry +20

Small-molecule androgen receptor downregulators as an approach to treatment of advanced prostate cancer

Robert H. Bradbury, Neil J. Hales, Alfred A. Rabow et al. · Bioorganic & Medicinal Chemistry Letters · 2011 · 44 citations

Urology, Genitourinary Cancer, Medicine +7

Intermittent High-Dose Scheduling of AZD8835, a Novel Selective Inhibitor of PI3Kα and PI3Kδ, Demonstrates Treatment Strategies for <i>PIK3CA</i> -Dependent Breast Cancers

Kevin Hudson, Urs J. Hancox, Cath Trigwell et al. · Molecular Cancer Therapeutics · 2016 · 42 citations · Full text