Iain Simpson

Identification and Characterization of Dual Inhibitors of the USP25/28 Deubiquitinating Enzyme Subfamily

Jonathan D.J. Wrigley, Gérald Gavory, Iain Simpson et al. · ACS Chemical Biology · 2017 · 84 citations · Full text

Aldo-keto Reductase, Immunology, Molecular Biology +19

Discovery of a Potent and Selective Oral Inhibitor of ERK1/2 (AZD0364) That Is Efficacious in Both Monotherapy and Combination Therapy in Models of Nonsmall Cell Lung Cancer (NSCLC)

Richard A. Ward, Mark J. Anderton, Paul A. Bethel et al. · Journal of Medicinal Chemistry · 2019 · 75 citations · Full text

Catalytic amidation of unactivated ester derivatives mediated by trifluoroethanol

Nicola Caldwell, Craig Jamieson, Iain Simpson et al. · Chemical Communications · 2015 · 56 citations

Chemical Engineering, Cross-coupling Reaction, Mechanistic Studies +10

Organobase-Catalyzed Amidation of Esters with Amino Alcohols

Nicola Caldwell, Craig Jamieson, Iain Simpson et al. · Organic Letters · 2013 · 54 citations

A modular lead-oriented synthesis of diverse piperazine, 1,4-diazepane and 1,5-diazocane scaffolds

Thomas James, Paul MacLellan, George M. Burslem et al. · Organic & Biomolecular Chemistry · 2014 · 53 citations