Jonathan D.J. Wrigley

Author

Also Known As

Jonathan D. J. Wrigley, Jonathan D. Wrigley, Jonathan D.J. WRIGLEY, Jonathan D.J. Wrigley, Jonathan Wrigley, Wrigley, J., Wrigley, Jonathan

Publications

1.3K

Citations

H-Index

Concepts

All Affiliations

MSD (UK) Limited (United Kingdom)Merck & Co., Inc., Rahway, NJ, USA (United States)AstraZeneca (United Kingdom)University of Leeds AstraZeneca (Sweden)

About

Jonathan D.J. Wrigley is an author at MSD (UK) Limited (United Kingdom) specializing in natural sciences, biochemistry, and medicine.

Top Concepts

#	Concept	H-Index	Publications	Citations
1	Natural Sciences	13	13	642
2	Biochemistry	12	12	629
3	Medicine	11	11	540
4	Chemical Biology	5	5	268
5	Cell Biology	2	2	97

Jonathan D.J. Wrigley

Publications

1.3K

Citations

H-Index

Page 1

	Year	Citations
Selected Non-steroidal Anti-inflammatory Drugs and Their Derivatives Target γ-Secretase at a Novel Site Dirk Beher, Earl E. Clarke, Jonathan D.J. Wrigley, Journal of Biological Chemistry	2004	178
BE-FLARE: a fluorescent reporter of base editing activity reveals editing characteristics of APOBEC3A and APOBEC3B Matthew A. Coelho, Songyuan Li, Luna Simona Pane, BMC Biology	2018	95
Pharmacological Knock-down of the Presenilin 1 Heterodimer by a Novel γ-Secretase Inhibitor Dirk Beher, Jonathan D.J. Wrigley, Alan Nadin, Journal of Biological Chemistry	2001	85
Identification and Characterization of Dual Inhibitors of the USP25/28 Deubiquitinating Enzyme Subfamily Jonathan D.J. Wrigley, Gérald Gavory, Iain Simpson, ACS Chemical Biology Aldo-keto ReductaseImmunologyMolecular BiologyUsp28 InhibitionChemical Biology	2017	84
Generation of C‐terminally truncated amyloid‐β peptides is dependent on γ‐secretase activity Dirk Beher, Jonathan D.J. Wrigley, Andrew P. Owens, Journal of Neurochemistry Protein SecretionAlzheimer's DiseaseBiochemistryProtein FoldingNatural Sciences	2002	82
In Vitro Characterization of the Presenilin-Dependent γ-Secretase Complex Using a Novel Affinity Ligand Dirk Beher, Michael Fricker, Alan Nadin, Biochemistry Vitro CharacterizationProtein SecretionProtein AssemblyMolecular BiologyProtein Folding	2003	80
4-Substituted cyclohexyl sulfones as potent, orally active γ-secretase inhibitors Ian Churcher, Dirk Beher, Jonathan D. Best, Bioorganic & Medicinal Chemistry Letters Medicinal ChemistryBiochemistryMedicineNatural SciencesPharmacological Agent	2005	78
Peripherin/rds Influences Membrane Vesicle Morphology Jonathan D.J. Wrigley, Tanweer Ahmed, Claire L. Nevett, Journal of Biological Chemistry	2000	75
Mapping the sugar dependency for rational generation of a DNA-RNA hybrid-guided Cas9 endonuclease Fernando Orden Rueda, Michał Biśta, Matthew D. Newton, Nature Communications	2017	69
Design and Synthesis of Highly Potent Benzodiazepine γ-Secretase Inhibitors: Preparation of (2<i>S</i>,3<i>R</i>)-3-(3,4- Difluorophenyl)-2-(4-fluorophenyl)-4- hydroxy-<i>N</i>-((3<i>S</i>)-1-methyl-2-oxo-5- phenyl-2,3-dihydro-1<i>H</i>-benzo[<i>e</i>][1,4]- diazepin-3-yl)butyramide by Use of an Asymmetric Ireland−Claisen Rearrangement Ian Churcher, Susie Williams, Sonia Kerrad, Journal of Medicinal Chemistry Vitro Potency3,4- DifluorophenylOrganic ChemistryPharmacotherapyHeterocycle Chemistry	2003	62

Page 1