Jonathan D.J. Wrigley

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Publications

Citations

1.3K

H-Index

Active since

2000

Affiliations

Merck & Co., Inc., Rahway, NJ, USA (United States)(Current)

MSD (UK) Limited (United Kingdom)

AstraZeneca (United Kingdom)

AstraZeneca (Singapore)

University of Leeds

Jonathan D.J. Wrigley is an author at Merck & Co., Inc., Rahway, NJ, USA (United States) specializing in life sciences, enzyme inhibition, and gamma secretase inhibition.

ORCID

Publications per year

2000–2018

Publications

Selected Non-steroidal Anti-inflammatory Drugs and Their Derivatives Target γ-Secretase at a Novel Site

Dirk Beher, Earl E. Clarke, Jonathan D.J. Wrigley et al. · Journal of Biological Chemistry · 2004 · 178 citations · Full text

Life Sciences, Biochemistry, Pharmacology +17

BE-FLARE: a fluorescent reporter of base editing activity reveals editing characteristics of APOBEC3A and APOBEC3B

Matthew A. Coelho, Songyuan Li, Luna Simona Pane et al. · BMC Biology · 2018 · 98 citations · Full text

Life Sciences, Genetics, Molecular Biology +13

Identification and Characterization of Dual Inhibitors of the USP25/28 Deubiquitinating Enzyme Subfamily

Jonathan D.J. Wrigley, Gérald Gavory, Iain Simpson et al. · ACS Chemical Biology · 2017 · 88 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +15

Pharmacological Knock-down of the Presenilin 1 Heterodimer by a Novel γ-Secretase Inhibitor

Dirk Beher, Jonathan D.J. Wrigley, Alan Nadin et al. · Journal of Biological Chemistry · 2001 · 86 citations · Full text

Life Sciences, Neuroscience, Pharmacology +15

Generation of C‐terminally truncated amyloid‐β peptides is dependent on γ‐secretase activity

Dirk Beher, Jonathan D.J. Wrigley, Andrew P. Owens et al. · Journal of Neurochemistry · 2002 · 83 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

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