Earl E. Clarke - Concepedia

Concepedia

Author

Earl E. Clarke

MSD (UK) Limited (United Kingdom)ORCID

Also Known As

Clarke, E, E. Clarke, Earl Clarke, Earl E. Clarke

39

Publications

2.4K

Citations

21

H-Index

42

Concepts

All Affiliations

MSD (UK) Limited (United Kingdom)Merck & Co., Inc., Rahway, NJ, USA (United States)King's College London

EE

About

Earl E. Clarke is an author at MSD (UK) Limited (United Kingdom) specializing in medicine, natural sciences, and biochemistry.

Top Concepts

#	Concept	H-Index	Publications	Citations
1	Medicine	10	10	1.3K
2	Natural Sciences	10	10	1.3K
3	Biochemistry	10	10	1.3K
4	Chemical Biology	4	4	199
5	Engineering	1	1	13

Earl E. Clarke

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24

Publications

2.4K

Citations

21

H-Index

	Year	Citations
Involvement of Caspases in Proteolytic Cleavage of Alzheimer’s Amyloid-β Precursor Protein and Amyloidogenic Aβ Peptide Formation François G. Gervais, Daigen Xu, George S. Robertson, Cell Neurodegenerative DiseasesProtein FunctionAlzheimer's DiseaseProteolytic CleavageBiochemistry	1999	785
L-685,458, an Aspartyl Protease Transition State Mimic, Is a Potent Inhibitor of Amyloid β-Protein Precursor γ-Secretase Activity Mark S. Shearman, Dirk Beher, Earl E. Clarke, Biochemistry	2000	365
Selected Non-steroidal Anti-inflammatory Drugs and Their Derivatives Target γ-Secretase at a Novel Site Dirk Beher, Earl E. Clarke, Jonathan D.J. Wrigley, Journal of Biological Chemistry	2004	178
Neuronal RARβ Signaling Modulates PTEN Activity Directly in Neurons and via Exosome Transfer in Astrocytes to Prevent Glial Scar Formation and Induce Spinal Cord Regeneration Maria B. Goncalves, Tony Malmqvist, Earl E. Clarke, Journal of Neuroscience	2015	96
In Vitro Characterization of the Presenilin-Dependent γ-Secretase Complex Using a Novel Affinity Ligand Dirk Beher, Michael Fricker, Alan Nadin, Biochemistry Vitro CharacterizationProtein SecretionProtein AssemblyMolecular BiologyProtein Folding	2003	80
4-Substituted cyclohexyl sulfones as potent, orally active γ-secretase inhibitors Ian Churcher, Dirk Beher, Jonathan D. Best, Bioorganic & Medicinal Chemistry Letters Medicinal ChemistryBiochemistryMedicineNatural SciencesPharmacological Agent	2005	78
Amyloid β inhibits retinoic acid synthesis exacerbating <scp>A</scp>lzheimer disease pathology which can be attenuated by an retinoic acid receptor α agonist Maria B. Goncalves, Earl E. Clarke, Carl Hobbs, European Journal of Neuroscience Amyloid βRetinoic Acid ReceptorImmunologyRetinoic AcidNeurochemical Biomarkers	2013	76
Retinoic acid receptor‐α signalling antagonizes both intracellular and extracellular amyloid‐β production and prevents neuronal cell death caused by amyloid‐β Christopher I Jarvis, Maria B. Goncalves, Earl E. Clarke, European Journal of Neuroscience	2010	75
Drug repurposing for Alzheimer’s disease based on transcriptional profiling of human iPSC-derived cortical neurons Gareth Williams, Ariana Gatt, Earl E. Clarke, Translational Psychiatry	2019	71
Design and Synthesis of Highly Potent Benzodiazepine γ-Secretase Inhibitors: Preparation of (2<i>S</i>,3<i>R</i>)-3-(3,4- Difluorophenyl)-2-(4-fluorophenyl)-4- hydroxy-<i>N</i>-((3<i>S</i>)-1-methyl-2-oxo-5- phenyl-2,3-dihydro-1<i>H</i>-benzo[<i>e</i>][1,4]- diazepin-3-yl)butyramide by Use of an Asymmetric Ireland−Claisen Rearrangement Ian Churcher, Susie Williams, Sonia Kerrad, Journal of Medicinal Chemistry Vitro Potency3,4- DifluorophenylOrganic ChemistryPharmacotherapyHeterocycle Chemistry	2003	62

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