Earl E. Clarke

Involvement of Caspases in Proteolytic Cleavage of Alzheimer’s Amyloid-β Precursor Protein and Amyloidogenic Aβ Peptide Formation

François G. Gervais, Daigen Xu, George S. Robertson et al. · Cell · 1999 · 785 citations · Full text

Neurodegenerative Diseases, Protein Function, Alzheimer's Disease +11

L-685,458, an Aspartyl Protease Transition State Mimic, Is a Potent Inhibitor of Amyloid β-Protein Precursor γ-Secretase Activity

Mark S. Shearman, Dirk Beher, Earl E. Clarke et al. · Biochemistry · 2000 · 365 citations

Selected Non-steroidal Anti-inflammatory Drugs and Their Derivatives Target γ-Secretase at a Novel Site

Dirk Beher, Earl E. Clarke, Jonathan D.J. Wrigley et al. · Journal of Biological Chemistry · 2004 · 178 citations · Full text

Neuronal RARβ Signaling Modulates PTEN Activity Directly in Neurons and via Exosome Transfer in Astrocytes to Prevent Glial Scar Formation and Induce Spinal Cord Regeneration

Maria B. Goncalves, Tony Malmqvist, Earl E. Clarke et al. · Journal of Neuroscience · 2015 · 96 citations · Full text

In Vitro Characterization of the Presenilin-Dependent γ-Secretase Complex Using a Novel Affinity Ligand

Dirk Beher, Michael Fricker, Alan Nadin et al. · Biochemistry · 2003 · 80 citations

Vitro Characterization, Protein Secretion, Protein Assembly +16