Concepedia

Mark S. Shearman

MS

Statistics

Publications

90

Citations

7.5K

H-Index

46

Active since

1987

Affiliations

Merck & Co., Inc., Rahway, NJ, USA (United States)(Current)

MSD (UK) Limited (United Kingdom)

United States Military Academy

Kobe University

Applied Genetic Technologies (United States)

Mark S. Shearman is an author at Merck & Co., Inc., Rahway, NJ, USA (United States) specializing in life sciences, biochemistry, and gamma secretase inhibition.

Publications per year

1987–2023

90

Publications

90

Photoactivated γ-secretase inhibitors directed to the active site covalently label presenilin 1

Yue‐Ming Li, Min Xu, Ming‐Tain Lai et al. · Nature · 2000 · 869 citations

, , +14

Involvement of Caspases in Proteolytic Cleavage of Alzheimer’s Amyloid-β Precursor Protein and Amyloidogenic Aβ Peptide Formation

François G. Gervais, Daigen Xu, George S. Robertson et al. · Cell · 1999 · 785 citations · Full text

, , +17

L-685,458, an Aspartyl Protease Transition State Mimic, Is a Potent Inhibitor of Amyloid β-Protein Precursor γ-Secretase Activity

Mark S. Shearman, Dirk Beher, Earl E. Clarke et al. · Biochemistry · 2000 · 367 citations

, , +17

Age-Related Impairment of Synaptic Transmission But Normal Long-Term Potentiation in Transgenic Mice that Overexpress the Human APP695SWE Mutant Form of Amyloid Precursor Protein

Stephen M. Fitzjohn, Robin A. Morton, Frederick M. Kuenzi et al. · Journal of Neuroscience · 2001 · 209 citations · Full text

, , +17

The Intracellular Component of Cellular 3‐(4,5‐Dimethylthiazol‐2‐yl)‐2,5‐Diphenyltetrazolium Bromide (MTT) Reduction Is Specifically Inhibited by β‐Amyloid Peptides

Mark S. Shearman, Stuart Hawtin, Vipula J. Tailor · Journal of Neurochemistry · 1995 · 204 citations

, , +17

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