Discovery of OSI-906: A Selective and Orally Efficacious Dual Inhibitor of the IGF-1 Receptor and Insulin Receptor

Mark J. Mulvihill, Andrew Cooke, Maryland Rosenfeld-Franklin, +10

Future Medicinal Chemistry

A novel, potent, and selective insulin-like growth factor-I receptor kinase inhibitor blocks insulin-like growth factor-I receptor signaling <i>in vitro</i> and inhibits insulin-like growth factor-I receptor–dependent tumor growth <i>in vivo</i>

Qunsheng Ji, Mark J. Mulvihill, Maryland Rosenfeld-Franklin, +11

Molecular Cancer Therapeutics

Igf-ii ExpressionSignal TransductionGrowth HormoneHuman Insulin ReceptorTumor Growth +12

OSI-930: A Novel Selective Inhibitor of Kit and Kinase Insert Domain Receptor Tyrosine Kinases with Antitumor Activity in Mouse Xenograft Models

Andrew J. Garton, Andrew P. Crew, Maryland Franklin, +26

Cancer Research

Mouse Xenograft ModelsAntitumor ActivityChemoprevention StrategySimilar PotencyCancer Biology +16

Novel 2-phenylquinolin-7-yl-derived imidazo[1,5-a]pyrazines as potent insulin-like growth factor-I receptor (IGF-IR) inhibitors

Mark J. Mulvihill, Qunsheng Ji, Heather Coate, +7

Bioorganic & Medicinal Chemistry

Medicinal ChemistryBiochemistryMedicineNatural SciencesRational Drug Design +7

SAR, Pharmacokinetics, Safety, and Efficacy of Glucokinase Activating 2-(4-Sulfonylphenyl)-<i>N</i>-thiazol-2-ylacetamides: Discovery of PSN-GK1

L. Bertram, Daniel Black, Paul Briner, +18

Journal of Medicinal Chemistry

Pharmaceutical ScienceGlycobiologyRobust GlucosePharmacotherapyInsulin Signaling +17

A Mobile Climbing Robot for High Precision Manufacture and Inspection of Aerostructures

T.S. White, Richard Alexander, Glenn Callow, +3

The International Journal of Robotics Research

Robot KinematicsRobotic SystemsEngineeringMechanical EngineeringField Robotics +17

A three-step tandem process for the synthesis of bicyclic γ-lactams

Fiona I. McGonagle, Lindsay Brown, Andrew Cooke, +1

Organic & Biomolecular Chemistry

1,3-Disubstituted-imidazo[1,5-a]pyrazines as insulin-like growth-factor-I receptor (IGF-IR) inhibitors

Mark J. Mulvihill, Qunsheng Ji, Doug Werner, +17

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryMedicineMechanism Of ActionPharmacotherapyDrug Development +4

Discovery of 7-aminofuro[2,3-c]pyridine inhibitors of TAK1: Optimization of kinase selectivity and pharmacokinetics

Keith R. Hornberger, Xin Chen, Andrew P. Crew, +16

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryBiochemistryMedicineNatural SciencesRational Drug Design +6

Imidazo[1,5-a]pyrazines: Orally efficacious inhibitors of mTORC1 and mTORC2

Andrew P. Crew, Shripad V. Bhagwat, Hanqing Dong, +19

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryBiochemistryMedicineNatural SciencesEfficacious Inhibitors +7