Novel 2-phenylquinolin-7-yl-derived imidazo[1,5-a]pyrazines as potent insulin-like growth factor-I receptor (IGF-IR) inhibitors

Mark J. Mulvihill, Qunsheng Ji, Heather Coate, +7

Bioorganic & Medicinal Chemistry

Medicinal ChemistryBiochemistryMedicineNatural SciencesRational Drug Design +7

GPR139, an Orphan Receptor Highly Enriched in the Habenula and Septum, Is Activated by the Essential Amino Acids l-Tryptophan and l-Phenylalanine

Changlu Liu, Pascal Bonaventure, Grace Lee, +16

Molecular Pharmacology

Pharmacological Blockade of the DP2 Receptor Inhibits Cigarette Smoke-Induced Inflammation, Mucus Cell Metaplasia, and Epithelial Hyperplasia in the Mouse Lung

Karin J. Stebbins, Alex Broadhead, Christopher Baccei, +14

Journal of Pharmacology and Experimental Therapeutics

Novel tricyclic antagonists of the prostaglandin D2 receptor DP2 with efficacy in a murine model of allergic rhinitis

Brian A. Stearns, Christopher Baccei, Gretchen Bain, +15

Bioorganic & Medicinal Chemistry Letters

InflammationAllergyAllergy MedicineMedicineMurine Model +8

Amino substituted analogs of 1-phenyl-3-phenylimino-2-indolones with potent galanin Gal3 receptor binding affinity and improved solubility

Michael J. Konkel, Mathivanan Packiarajan, Heidi Chen, +5

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryBioorganic ChemistryBiochemistryNatural SciencesMedicine +5

One-Pot Friedländer Quinoline Synthesis: Scope and Limitations

An‐Hu Li, David B. Beard, Heather Coate, +14

Synthesis

EngineeringCatalytic AmountBiochemistryOrganic ChemistryCatalysis +6

Identification and SAR of Glycine Benzamides as Potent Agonists for the GPR139 Receptor

Curt A. Dvorak, Heather Coate, Diane Nepomuceno, +8

ACS Medicinal Chemistry Letters

PharmacotherapyMedicinal ChemistryGlycine BenzamidesPharmacological StudyGpr139 Receptor +16

Pharmacology of JNJ-28583113: A novel TRPM2 antagonist

Lawrence Fourgeaud, Curt A. Dvorak, Malika Faouzi, +12

European Journal of Pharmacology

Molecular PharmacologyMedicineMechanism Of ActionNovel Trpm2 AntagonistPharmacotherapy +3

Imidazo[1,5-a]pyrazines: Orally efficacious inhibitors of mTORC1 and mTORC2

Andrew P. Crew, Shripad V. Bhagwat, Hanqing Dong, +19

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryBiochemistryMedicineNatural SciencesEfficacious Inhibitors +7

5-(2′-Pyridyl)-2-aminothiazoles: Alkyl amino sulfonamides and sulfamides as potent NPY5 antagonists

Mathivanan Packiarajan, Heather Coate, Mahesh Desai, +8

Bioorganic & Medicinal Chemistry Letters

EngineeringPotent Npy5 AntagonistsMedicineDrug DiscoveryPharmacological Agent +5