Concepedia

Interleukins 1β and 6 but not transforming growth factor-β are essential for the differentiation of interleukin 17–producing human T helper cells

Eva V. Acosta Rodríguez, Giorgio Napolitani, Antonio Lanzavecchia, Federica Sallusto

Nature Immunology · 2007 · 1.8K citations · 39 references

DOI

Concepts

References

39

Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells

Estelle Bettelli, Yijun Carrier, Wenda Gao et al. · Nature · 2006 · 6.9K citations

, , +16

Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha.

Federica Sallusto, Antonio Lanzavecchia · The Journal of Experimental Medicine · 1994 · 5.2K citations · Full text

, , +17

The Orphan Nuclear Receptor RORγt Directs the Differentiation Program of Proinflammatory IL-17+ T Helper Cells

Ivaylo I. Ivanov, Brent S. McKenzie, Liang Zhou et al. · Cell · 2006 · 5.1K citations · Full text

, , +16

Interleukin 17–producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages

Laurie E. Harrington, Robin D. Hatton, Paul R. Mangan et al. · Nature Immunology · 2005 · 4.7K citations

, , +17

A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17

Heon Park, Zhaoxia Li, Xuexian O. Yang et al. · Nature Immunology · 2005 · 4.2K citations · Full text

, , +17