Synthesis and antitumor activity of 7-ethyl-9-alkyl derivatives of camptothecin

Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I.

Y H Hsiang, Robert Hertzberg, Sidney M. Hecht et al. · Journal of Biological Chemistry · 1985 · 2.3K citations · Full text

Chromatin, Genome Instability, Dna Damage +12

Notes - Osmium Tetroxide-Catalyzed Periodate Oxidation of Olefinic Bonds

Raphael Pappo, D.M. Allen, René M. Lemieux et al. · The Journal of Organic Chemistry · 1956 · 661 citations

Chemical Engineering, Engineering, Chemical Analysis +10

The Novel Silatecan 7-<i>tert</i>-Butyldimethylsilyl-10-hydroxycamptothecin Displays High Lipophilicity, Improved Human Blood Stability, and Potent Anticancer Activity

David Bom, Dennis P. Curran, Stefan Kruszewski et al. · Journal of Medicinal Chemistry · 2000 · 155 citations

Homocamptothecins:  Synthesis and Antitumor Activity of Novel E-Ring-Modified Camptothecin Analogues

Olivier Lavergne, Laurence Lesueur‐Ginot, Francesc Pla Rodas et al. · Journal of Medicinal Chemistry · 1998 · 150 citations

Antitumor Activity, Chemoprevention Strategy, Tumor Growth Delay +17

Novel 7-Oxyiminomethyl Derivatives of Camptothecin with Potent in Vitro and in Vivo Antitumor Activity

Sabrina Dallavalle, Anna Maria Ferrari, Barbara Biasotti et al. · Journal of Medicinal Chemistry · 2001 · 103 citations

Medicinal Chemistry, Health Sciences, Position 7 +15