René M. Lemieux

Notes - Osmium Tetroxide-Catalyzed Periodate Oxidation of Olefinic Bonds

Raphael Pappo, D.M. Allen, René M. Lemieux et al. · The Journal of Organic Chemistry · 1956 · 664 citations

Natural Sciences, Chemistry, Catalysis +5

Discovery of AG-120 (Ivosidenib): A First-in-Class Mutant IDH1 Inhibitor for the Treatment of IDH1 Mutant Cancers

Janeta Popovici-Müller, René M. Lemieux, Erin Artin et al. · ACS Medicinal Chemistry Letters · 2018 · 444 citations · Full text

Medicine, Molecular Biology, Oncology +14

The electrocatalytic hydrogenation of fused poly cyclic aromatic compounds at Raney nickel electrodes: the influence of catalyst activation and electrolysis conditions

Denis Robin, Michel Comtois, Anna Martel et al. · Canadian Journal of Chemistry · 1990 · 75 citations

Natural Sciences, Chemical Engineering, Chemistry +17

Asymmetric Synthesis of (−)-Trichodiene. Generation of Vicinal Stereogenic Quaternary Centers via the Thio-Claisen Rearrangement

René M. Lemieux, A. I. MEYERS · Journal of the American Chemical Society · 1998 · 67 citations

Natural Sciences, Chemistry, Drug Discovery +14

AG-120, an Oral, Selective, First-in-Class, Potent Inhibitor of Mutant IDH1, Reduces Intracellular 2HG and Induces Cellular Differentiation in TF-1 R132H Cells and Primary Human IDH1 Mutant AML Patient Samples Treated Ex Vivo

Erica Hansen, Cyril Quivoron, Kim Straley et al. · Blood · 2014 · 48 citations

Medicine, Cancer Biology, Oncology +4