Laurence Lesueur‐Ginot

Genetic associations with human longevity at the APOE and ACE loci

François Schächter, Laurence Faure-Delanef, Frédérique Guénot et al. · Nature Genetics · 1994 · 1.1K citations

Biology, Genetic Associations, Lifespan Extension +10

Homocamptothecins:  Synthesis and Antitumor Activity of Novel E-Ring-Modified Camptothecin Analogues

Olivier Lavergne, Laurence Lesueur‐Ginot, Francesc Pla Rodas et al. · Journal of Medicinal Chemistry · 1998 · 150 citations

Antitumor Activity, Chemoprevention Strategy, Tumor Growth Delay +17

Homocamptothecin, an E-ring modified camptothecin with enhanced lactone stability, retains topoisomerase I-targeted activity and antitumor properties.

Laurence Lesueur‐Ginot, Danièle Demarquay, Róbert Kiss et al. · PubMed · 1999 · 109 citations

Chemoprevention Strategy, Cpt Analogues, Cell Death +16

BN 80245: An E-ring modified camptothecin with potent antiproliferative and topoisomerase I inhibitory activities

Olivier Lavergne, Laurence Lesueur‐Ginot, Francesc Pla Rodas et al. · Bioorganic & Medicinal Chemistry Letters · 1997 · 97 citations

Medicinal Chemistry, Health Sciences, Medicine +7

BN 80927: A novel homocamptothecin with inhibitory activities on both topoisomerase I and topoisomerase II

Olivier Lavergne, Jeremiah J. Harnett, Alain Rolland et al. · Bioorganic & Medicinal Chemistry Letters · 1999 · 54 citations

Medicine, Natural Sciences, Molecular Biology +5