Homocamptothecins:  Synthesis and Antitumor Activity of Novel E-Ring-Modified Camptothecin Analogues

Olivier Lavergne, Laurence Lesueur‐Ginot, Francesc Pla Rodas, +11

Journal of Medicinal Chemistry

Antitumor ActivityChemoprevention StrategyTumor Growth DelayHeterocycle ChemistryPharmaceutical Chemistry +15

Homocamptothecin, an E-ring modified camptothecin with enhanced lactone stability, retains topoisomerase I-targeted activity and antitumor properties.

Laurence Lesueur‐Ginot, Danièle Demarquay, Róbert Kiss, +6

PubMed

Chemoprevention StrategyCpt AnaloguesCell DeathE-ring Modified CamptothecinToxicological Mechanism +14

BN 80245: An E-ring modified camptothecin with potent antiproliferative and topoisomerase I inhibitory activities

Olivier Lavergne, Laurence Lesueur‐Ginot, Francesc Pla Rodas, +1

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryHealth SciencesMedicineE-ring Modified CamptothecinAnti-cancer Agent +5

Inhibition of Heterotrimeric G Protein Signaling by a Small Molecule Acting on Gα Subunit

Mohammed Akli Ayoub, Marjorie Damian, Christian Gespach, +6

Journal of Biological Chemistry

Molecular RegulationG Protein HeterotrimerSmall Molecule ActingCell SignalingMolecular Signaling +18

Topoisomerase I-Mediated Antiproliferative Activity of Enantiomerically Pure Fluorinated Homocamptothecins

Olivier Lavergne, Danièle Demarquay, Christian Bailly, +11

Journal of Medicinal Chemistry

Homocamptothecin, an E-Ring-Modified Camptothecin Analogue, Generates New Topoisomerase I-Mediated DNA Breaks

Christian Bailly, Amélie Lansiaux, Laurent Dassonneville, +5

Biochemistry

Inhibition of human tumor cell growth <i>in vivo</i> by an orally bioavailable inhibitor of CDC25 phosphatases

Marie-Christine Brézak, Muriel Quaranta, Marie-Odile Contour-Galcéra, +6

Molecular Cancer Therapeutics

A Novel Synthetic Inhibitor of CDC25 Phosphatases

Marie-Christine Brézak, Muriel Quaranta, Odile Mondésert, +11

Cancer Research

BN 80927: A novel homocamptothecin with inhibitory activities on both topoisomerase I and topoisomerase II

Olivier Lavergne, Jeremiah J. Harnett, Alain Rolland, +6

Bioorganic & Medicinal Chemistry Letters

MedicineNatural SciencesMolecular BiologyChemical BiologyPharmacology +3

IRC‐083864, a novel bis quinone inhibitor of CDC25 phosphatases active against human cancer cells

Marie-Christine Brézak, Annie Valette, Muriel Quaranta, +8

International Journal of Cancer

Medicinal ChemistryDrug TargetingChemoprevention StrategyMedicineTumor Growth +13