Y H Hsiang

Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I.

Y H Hsiang, Robert Hertzberg, Sidney M. Hecht et al. · Journal of Biological Chemistry · 1985 · 2.4K citations · Full text

Life Sciences, Cell Biology, Molecular Biology +15

Arrest of replication forks by drug-stabilized topoisomerase I-DNA cleavable complexes as a mechanism of cell killing by camptothecin.

Y H Hsiang, M G Lihou, Leroy F. Liu · PubMed · 1989 · 1K citations

Life Sciences, Cell Biology, Molecular Biology +17

DNA topoisomerase I-mediated DNA cleavage and cytotoxicity of camptothecin analogues.

Y H Hsiang, Leroy F. Liu, Monroe E. Wall et al. · PubMed · 1989 · 341 citations

Medicine, Oncology, Pharmacology +13

Proliferation-dependent regulation of DNA topoisomerase II in cultured human cells.

Y H Hsiang, Haiyan Wu, Leroy F. Liu · PubMed · 1988 · 247 citations

Life Sciences, Cell Biology, Molecular Biology +7

DNA damage by antitumor acridines mediated by mammalian DNA topoisomerase II.

Thomas C. Rowe, Grace L. Chen, Y H Hsiang et al. · PubMed · 1986 · 236 citations

Medicine, Molecular Biology, Oncology +15