Antibiotics-Driven Gut Microbiome Perturbation Alters Immunity to Vaccines in Humans

Thomas Hagan, Mario Cortese, Nadine Rouphael, +26

Cell

ProbioticDysbiosisMucosal ImmunologyAntibioticsGut Microbiology +8

Structure of a yeast spliceosome at 3.6-angstrom resolution

Chuangye Yan, Jing Hang, Ruixue Wan, +3

Science

Yeast SpliceosomeU5 SnrnpProtein FoldingMedicineCentral Spliceosome +11

Targeting Epigenetic Crosstalk as a Therapeutic Strategy for EZH2-Aberrant Solid Tumors

Xun Huang, Juan Yan, Min Zhang, +16

Cell

ChromatinOncologyMedicineEzh2-aberrant Solid TumorsEpigenetic Change +10

Inactivation of Murine Usp1 Results in Genomic Instability and a Fanconi Anemia Phenotype

Jung Min Kim, Kalindi Parmar, Min Huang, +4

Developmental Cell

Genome InstabilityFanconi Anemia PhenotypeGenetic DisorderGeneticsGenomic Mechanism +5

Nanoliter-Scale Oil-Air-Droplet Chip-Based Single Cell Proteomic Analysis

Ziyi Li, Min Huang, Xiukun Wang, +4

Analytical Chemistry

Single Cell SamplesEngineeringSample PretreatmentBiological Mass SpectrometryProteomic Technology +15

Luteolin and its derivative apigenin suppress the inducible PD-L1 expression to improve anti-tumor immunity in KRAS-mutant lung cancer

Zebo Jiang, Wenjun Wang, Cong Xu, +14

Cancer Letters

Derivative ApigeninMedicineOncogenic AgentImmunologyTumor Immunity +8

Chemotherapy-induced intestinal inflammatory responses are mediated by exosome secretion of double-strand DNA via AIM2 inflammasome activation

Qiaoshi Lian, Jun Xu, Shanshan Yan, +7

Cell Research

InflammationAnti-inflammatoryImmunologyExtracellular MicrovesiclesGut Barrier +6

Multiple Signaling Roles of CD3ε and Its Application in CAR-T Cell Therapy

Wei Wu, Qiuping Zhou, Takeya Masubuchi, +15

Cell

Signal TransductionT-regulatory CellImmunologyCar-t Cell TherapyImmunologic Mechanism +10

Small-Molecule Inhibitors of USP1 Target ID1 Degradation in Leukemic Cells

Helena Mistry, Grace Hsieh, Sara J. Buhrlage, +8

Molecular Cancer Therapeutics

Usp1 InhibitorProteasome DegradationMedicineNatural SciencesSmall Molecules +12

Feedback Activation of Leukemia Inhibitory Factor Receptor Limits Response to Histone Deacetylase Inhibitors in Breast Cancer

Hanlin Zeng, Jia Qu, Nan Jin, +12

Cancer Cell

Breast OncologyMedicineFeedback ActivationPharmacologyHistone Deacetylase Inhibitors +6