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Discovery of heterocyclic ureas as a new class of raf kinase inhibitors: identification of a second generation lead by a combinatorial chemistry approach

Roger A. Smith, J A Barbosa, Cheri L. Blum, Mark A. Bobko, Yolanda Caringal, Robert Dally, Jeffrey S. Johnson, Michael Katz, Nancy Kennure, Jill Kingery-Wood,

Bioorganic & Medicinal Chemistry Letters · 2001 · 85 citations · 9 references

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References

9

ras oncogenes in human cancer: a review.

Joyce Bos · PubMed · 1989 · 5.1K citations

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Antitumor activity of a phosphorothioate antisense oligodeoxynucleotide targeted against C-raf kinase

Brett P. Monia, Joseph F. Johnston, Thomas Geiger et al. · Nature Medicine · 1996 · 453 citations

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Reconstitution of the Raf-1-MEK-ERK signal transduction pathway in vitro.

Susan G. Macdonald, Craig M. Crews, Lin Wu et al. · Molecular and Cellular Biology · 1993 · 250 citations · Full text

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The discovery of potent cRaf1 kinase inhibitors

Karen Lackey, Michael Cory, Ronda G. Davis et al. · Bioorganic & Medicinal Chemistry Letters · 2000 · 205 citations · Full text

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Discovery of heterocyclic ureas as a new class of raf kinase inhibitors: identification of a second generation lead by a combinatorial chemistry approach

Roger A. Smith, J A Barbosa, Cheri L. Blum et al. · Bioorganic & Medicinal Chemistry Letters · 2001 · 85 citations · Full text

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