Concepedia

Combinatorial Lead Generation

Combinatorial Lead Generation is a methodological approach in drug discovery that systematically combines chemical building blocks to create diverse compound libraries for high-throughput screening against biological targets to identify novel lead molecules.

100

Publications

5.1K

Citations

508

Authors

129

Institutions

Publications per year

2017–2026

5

Parents

Publications

100

RECAPRetrosynthetic Combinatorial Analysis Procedure:  A Powerful New Technique for Identifying Privileged Molecular Fragments with Useful Applications in Combinatorial Chemistry

Xiao Qing Lewell, Duncan B. Judd, Michael M. Hann · Journal of Chemical Information and Computer Sciences · 1998 · 701 citations

, , +13

Novel CFTR Chloride Channel Activators Identified by Screening of Combinatorial Libraries Based on Flavone and Benzoquinolizinium Lead Compounds

Luis J. V. Galietta, Mark F. Springsteel, Masahiro Eda et al. · Journal of Biological Chemistry · 2001 · 213 citations · Full text

, , +14

De Novo Design at the Edge of Chaos

Petra Schneider, Gisbert Schneider · Journal of Medicinal Chemistry · 2016 · 168 citations · Full text

, , +13

Discovery and Investigation of Anticancer Ruthenium–Arene Schiff-Base Complexes via Water-Promoted Combinatorial Three-Component Assembly

Mun Juinn Chow, Cynthia Licona, Daniel Yuan Qiang Wong et al. · Journal of Medicinal Chemistry · 2014 · 156 citations

, , +17

Learning from our mistakes: The ‘unknown knowns’ in fragment screening

Ben Davis, Daniel A. Erlanson · Bioorganic & Medicinal Chemistry Letters · 2013 · 145 citations · Full text

, , +17

1–5 of 100

Authors

508

  1. MJ
    Mark J. Kurth

    University of California, Davis, United States

    4 publications · 367 citations

    4

    h-index

  2. GS
    Gisbert Schneider

    ETH Zurich, Switzerland

    3 publications · 215 citations

    3

    h-index

  3. LJ
    Luis J. V. Galietta

    Istituto Giannina Gaslini, Italy

    2 publications · 269 citations

    2

    h-index

  4. MP
    Maurizio Pellecchia

    Sanford Burnham Prebys Medical Discovery Institute, United States

    2 publications · 110 citations

    2

    h-index

  5. AS
    A. S. Verkman

    University of California, San Francisco, United States

    2 publications · 269 citations

    2

    h-index

1–5 of 508

Institutions

129

  1. Scripps Research Institute

    San Diego, United States

    3 h-index

    10 publications

    441 citations

  2. Sichuan University

    Chengdu, China

    3 h-index

    7 publications

    163 citations

  3. Array BioPharma (United States)

    Boulder, United States

    3 h-index

    3 publications

    102 citations

  4. University of Basel

    Basel, Switzerland

    3 h-index

    13 publications

    396 citations

  5. University of California San Diego

    San Diego, United States

    3 h-index

    13 publications

    706 citations

  6. University of California, Davis

    Davis, United States

    3 h-index

    15 publications

    1.8K citations

  7. University of California, San Francisco

    San Francisco, United States

    2 h-index

    4 publications

    538 citations

  8. National University of Singapore

    Singapore, Singapore

    2 h-index

    5 publications

    638 citations

1–8 of 129

Venues

  1. Journal of Medicinal Chemistry

    9 publications · 571 citations

    8

    h-index

  2. PubMed

    Repository · 7 publications · 133 citations

    7

    h-index

  3. Bioorganic & Medicinal Chemistry Letters

    7 publications · 424 citations

    7

    h-index

  4. Journal of Chemical Information and Modeling

    JCIM · 5 publications · 258 citations

    5

    h-index

  5. Molecular Diversity

    4 publications · 100 citations

    4

    h-index

1–5