Discovery of heterocyclic ureas as a new class of raf kinase inhibitors: identification of a second generation lead by a combinatorial chemistry approach

Roger A. Smith, J A Barbosa, Cheri L. Blum, +15

Bioorganic & Medicinal Chemistry Letters

Combinatorial ChemistryMedicinal ChemistryDrug TargetBioorganic ChemistryBiochemistry +10

Structure-Based Design of Potent and Selective 3-Phosphoinositide-Dependent Kinase-1 (PDK1) Inhibitors

Jesús R. Medina, Christopher Becker, Charles W. Blackledge, +22

Journal of Medicinal Chemistry

Drug TargetChemoprevention StrategyChemical BiologyMedicinal ChemistryDrug Design +18

Solid-phase synthesis of a library of piperazinediones and diazepinediones via kaiser oxime resin

Roger A. Smith, Mark A. Bobko, Wendy Lee

Bioorganic & Medicinal Chemistry Letters

Combinatorial ChemistryChemical EngineeringSolid-phase SynthesisEngineeringOrganic Chemistry +5

Discovery and SAR of novel Naphthyridines as potent inhibitors of spleen tyrosine kinase (SYK)

Charles L. Cywin, Baoping Zhao, Daniel W. McNeil, +14

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryPharmaceutical ChemistryDrug TargetBiochemistryNatural Sciences +10

Discovery of a new class of p38 kinase inhibitors

Jacques Dumas, Robert Sibley, Bernd Riedl, +15

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryDrug TargetP38 Kinase InhibitorsMedicineRational Drug Design +3

5,7-Dimethoxy-3-(4-Pyridinyl)Quinoline Is a Potent and Selective Inhibitor of Human Vascular .beta.-Type Platelet-Derived Growth Factor Receptor Tyrosine Kinase

Roland E. Dolle, Joseph A. Dunn, Mark A. Bobko, +13

Journal of Medicinal Chemistry

Altmetric Attention ScorePharmacotherapyMolecular PharmacologyThrombosisMedicinal Chemistry +17

Discovery, SAR and X-ray structure of 1H-benzimidazole-5-carboxylic acid cyclohexyl-methyl-amides as inhibitors of inducible T-cell kinase (Itk)

K.J.M. Moriarty, Hidenori Takahashi, Steven S. Pullen, +21

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryDrug TargetBiochemistryX-ray StructureNatural Sciences +10

Isolation and structure elucidation of two new calpain inhibitors from Streptomyces griseus.

Maria E. Alvarez, David R. Houck, CAROLE B. WHITE, +7

The Journal of Antibiotics

Structure, determination, pharmacological evaluation, and structure-activity studies of a new cyclic peptide substance P antagonist containing the new amino acid 3-prenyl-.beta.-hydroxytyrosine isolated from Aspergillus flavipes

Colin J. Barrow, Muriel S. Doleman, Mark A. Bobko, +1

Journal of Medicinal Chemistry

Synthesis, Characterization, and Conformational Analysis of the D/L-Tic7 Stereoisomers of Bradykinin Receptor Antagonist D-Arg0[Hyp3,Thi5,D-Tic7,Oic8]bradykinin

David G. Sawutz, Joseph M. Salvino, Peter R. Seoane, +6

Biochemistry

D/l-tic7 StereoisomersImmunologyPharmaceutical ChemistryMolecular PharmacologyMedicinal Chemistry +16