Jesús R. Medina

Discovery of 7-Methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3-dihydro-1<i>H</i>-indol-5-yl)-7<i>H</i>-pyrrolo[2,3-<i>d</i>]pyrimidin-4-amine (GSK2606414), a Potent and Selective First-in-Class Inhibitor of Protein Kinase R (PKR)-like Endoplasmic Reticulum Kinase (PERK)

Jeffrey M. Axten, Jesús R. Medina, Yanhong Feng et al. · Journal of Medicinal Chemistry · 2012 · 601 citations · Full text

Chemoprevention Strategy, Chemical Biology, Pharmaceutical Chemistry +24

Discovery of GSK2656157: An Optimized PERK Inhibitor Selected for Preclinical Development

Jeffrey M. Axten, Stuart P. Romeril, Arthur Y. L. Shu et al. · ACS Medicinal Chemistry Letters · 2013 · 224 citations · Full text

Drug Discovery Program, Tumor Biology, Physical Properties +18

Multigram Synthesis of the C29−C51 Subunit and Completion of the Total Synthesis of Altohyrtin C (Spongistatin 2)

Clayton H. Heathcock, Mark McLaughlin, Jesús R. Medina et al. · Journal of the American Chemical Society · 2003 · 83 citations

Bioorganic Chemistry, Engineering, Molecular Biology +17

9-Borabicyclo[3.3.2]decanes and the Asymmetric Hydroboration of 1,1-Disubstituted Alkenes

Ana Z. González, José G. Román, Eduvigis González et al. · Journal of the American Chemical Society · 2008 · 79 citations

Structure-Based Design of Potent and Selective 3-Phosphoinositide-Dependent Kinase-1 (PDK1) Inhibitors

Jesús R. Medina, Christopher Becker, Charles W. Blackledge et al. · Journal of Medicinal Chemistry · 2011 · 53 citations · Full text

Drug Target, Chemoprevention Strategy, Chemical Biology +20