A Scaleable Synthesis of BAY 43-9006:  A Potent Raf Kinase Inhibitor for the Treatment of Cancer

Donald Bankston, Jacques Dumas, Reina Natero, +3

Organic Process Research & Development

Other Urea TargetsMedicinal ChemistryBioorganic ChemistryScaleable SynthesisMedicine +13

Synthesis and structure activity relationships of novel small molecule cathepsin D inhibitors

Jacques Dumas, David R. Brittelli, Jinshan Chen, +6

Bioorganic & Medicinal Chemistry Letters

BiochemistryNatural SciencesMedicineStructure Activity RelationshipsNon-peptide Ligand +5

1-Phenyl-5-pyrazolyl ureas: potent and selective p38 kinase inhibitors

Jacques Dumas, Holia Hatoum‐Mokdad, Robert Sibley, +14

Bioorganic & Medicinal Chemistry Letters

Molecular PharmacologyMedicinal Chemistry1-Phenyl-5-pyrazolyl UreasMedicinePharmacological Agent +4

Discovery of a new class of p38 kinase inhibitors

Jacques Dumas, Robert Sibley, Bernd Riedl, +15

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryDrug TargetP38 Kinase InhibitorsMedicineRational Drug Design +3

Omega-carboxypyridyl substituted ureas as Raf kinase inhibitors

Uday R. Khire, Donald Bankston, J A Barbosa, +23

Bioorganic & Medicinal Chemistry Letters

Molecular PharmacologyBiochemistryMedicineRaf Kinase InhibitorsMechanism Of Action +3

A novel estrogen receptor ligand template

Robert Sibley, Holia Hatoum‐Mokdad, Robert Schoenleber, +6

Bioorganic & Medicinal Chemistry Letters

MedicineHormonal ReceptorReceptor (Biochemistry)Non-peptide LigandEndocrinology +2

4,5-Disubstituted cis-pyrrolidinones as inhibitors of type II 17β-hydroxysteroid dehydrogenase. Part 2. SAR

David Gunn, Christiana Akuche, Jeremy L. Baryza, +27

Bioorganic & Medicinal Chemistry Letters

Molecular PharmacologyMedicinal ChemistryBioorganic ChemistryBiochemistryNatural Sciences +8

Synthesis and pharmacological characterization of a potent, orally active p38 kinase inhibitor

Jacques Dumas, Holia Hatoum‐Mokdad, Robert Sibley, +27

Bioorganic & Medicinal Chemistry Letters

Molecular PharmacologyPharmacological CharacterizationBiochemistryMedicinePharmacological Agent +5

Discovery of a Series of Pyrazinone RORγ Antagonists and Identification of the Clinical Candidate BI 730357

Christian Harcken, Johanna Csengery, Michael Turner, +20

ACS Medicinal Chemistry Letters