Discovery of AZD9833, a Potent and Orally Bioavailable Selective Estrogen Receptor Degrader and Antagonist

James S. Scott, Amber Balazs, Bernard Barlaam, +42

Journal of Medicinal Chemistry

Synthesis and structure activity relationships of novel small molecule cathepsin D inhibitors

Jacques Dumas, David R. Brittelli, Jinshan Chen, +6

Bioorganic & Medicinal Chemistry Letters

BiochemistryNatural SciencesMedicineStructure Activity RelationshipsNon-peptide Ligand +5

1-Phenyl-5-pyrazolyl ureas: potent and selective p38 kinase inhibitors

Jacques Dumas, Holia Hatoum‐Mokdad, Robert Sibley, +14

Bioorganic & Medicinal Chemistry Letters

Molecular PharmacologyMedicinal Chemistry1-Phenyl-5-pyrazolyl UreasMedicinePharmacological Agent +4

A novel estrogen receptor ligand template

Robert Sibley, Holia Hatoum‐Mokdad, Robert Schoenleber, +6

Bioorganic & Medicinal Chemistry Letters

MedicineHormonal ReceptorReceptor (Biochemistry)Non-peptide LigandEndocrinology +2

Discovery of Efficacious <i>Pseudomonas aeruginosa</i>-Targeted Siderophore-Conjugated Monocarbams by Application of a Semi-mechanistic Pharmacokinetic/Pharmacodynamic Model

Kerry E. Murphy-Benenato, Pratik Bhagunde, April Chen, +23

Journal of Medicinal Chemistry

Lead CompoundsNew AgentsAntimicrobial ChemotherapyPharmacodynamic ModelingDrug Resistance +19

Synthesis and pharmacological characterization of a potent, orally active p38 kinase inhibitor

Jacques Dumas, Holia Hatoum‐Mokdad, Robert Sibley, +27

Bioorganic & Medicinal Chemistry Letters

Molecular PharmacologyPharmacological CharacterizationBiochemistryMedicinePharmacological Agent +5

Addition of Fluorine and a Late-Stage Functionalization (LSF) of the Oral SERD AZD9833

James S. Scott, Bernard Barlaam, Paul R. J. Davey, +11

ACS Medicinal Chemistry Letters

Late Stage FunctionalizationPharmaceutical ScienceBioorganic ChemistryOrganic ChemistryOral Serd Azd9833 +15

Discovery of a Potent and Orally Bioavailable Zwitterionic Series of Selective Estrogen Receptor Degrader-Antagonists

James S. Scott, Darren Stead, Bernard Barlaam, +39

Journal of Medicinal Chemistry

Discovery and Optimization of Pyrazine Carboxamide AZ3246, a Selective HPK1 Inhibitor

Jason D. Shields, David Baker, Amber Balazs, +61

Journal of Medicinal Chemistry

Photoredox Catalysis: 1,4-Conjugate Addition of <i>N</i>-Methyl Radicals to Electron-Deficient Olefins via Decarboxylation of <i>N</i>-Substituted Acetic Acids

Lakshmaiah Gingipalli, Jeffrey A. Boerth, David M. Emmons, +10

Organic Letters