April Chen

Discovery and Optimization of Triazolopyridazines as Potent and Selective Inhibitors of the c-Met Kinase

Brian K. Albrecht, Jean-Christophe Harmange, David Bauer et al. · Journal of Medicinal Chemistry · 2008 · 138 citations · Full text

Combinatorial Chemistry, Chemoprevention Strategy, Selective Inhibitors +22

Rational design of a new antibiotic class for drug-resistant infections

Thomas F. Durand-Réville, Alita A. Miller, John P. O’Donnell et al. · Nature · 2021 · 134 citations

Antimicrobial Susceptibility, Antibiotics, Rational Design +8

Discovery of a Potent, Selective, and Orally Bioavailable c-Met Inhibitor: 1-(2-Hydroxy-2-methylpropyl)-<i>N</i>-(5-(7-methoxyquinolin-4-yloxy)pyridin-2-yl)-5-methyl-3-oxo-2-phenyl-2,3-dihydro-1<i>H</i>-pyrazole-4-carboxamide (AMG 458)

Longbin Liu, Aaron Siegmund, Ning Xi et al. · Journal of Medicinal Chemistry · 2008 · 94 citations · Full text

Pharmaceutical Science, Metabolic Hot Spot, Chemoprevention Strategy +21

Pharmacodynamic Profiling of a Siderophore-Conjugated Monocarbam in Pseudomonas aeruginosa: Assessing the Risk for Resistance and Attenuated Efficacy

Aryun Kim, Amy Kutschke, David E. Ehmann et al. · Antimicrobial Agents and Chemotherapy · 2015 · 76 citations · Full text

Microbial Pathogens, Antimicrobial Chemotherapy, Adaptive Resistance +25

Discovery of an Orally Available Diazabicyclooctane Inhibitor (ETX0282) of Class A, C, and D Serine β-Lactamases

Thomas F. Durand-Réville, Janelle Comita-Prevoir, Jing Zhang et al. · Journal of Medicinal Chemistry · 2020 · 59 citations · Full text