Amy Kutschke

Responding to the challenge of untreatable gonorrhea: ETX0914, a first-in-class agent with a distinct mechanism-of-action against bacterial Type II topoisomerases

Gregory S. Basarab, Günther Kern, John McNulty et al. · Scientific Reports · 2015 · 100 citations · Full text

Characterization of the Novel DNA Gyrase Inhibitor AZD0914: Low Resistance Potential and Lack of Cross-Resistance in Neisseria gonorrhoeae

Richard A. Alm, Sushmita D. Lahiri, Amy Kutschke et al. · Antimicrobial Agents and Chemotherapy · 2014 · 93 citations · Full text

Pharmacodynamic Profiling of a Siderophore-Conjugated Monocarbam in Pseudomonas aeruginosa: Assessing the Risk for Resistance and Attenuated Efficacy

Aryun Kim, Amy Kutschke, David E. Ehmann et al. · Antimicrobial Agents and Chemotherapy · 2015 · 76 citations · Full text

Microbial Pathogens, Antimicrobial Chemotherapy, Adaptive Resistance +25

<i>In Vitro</i> Antibacterial Activity of AZD0914, a New Spiropyrimidinetrione DNA Gyrase/Topoisomerase Inhibitor with Potent Activity against Gram-Positive, Fastidious Gram-Negative, and Atypical Bacteria

Michael D. Huband, Patricia A. Bradford, Linda G. Otterson et al. · Antimicrobial Agents and Chemotherapy · 2014 · 73 citations · Full text

Molecular Biology, Antimicrobial Chemotherapy, Drug Resistance +23

Discovery of Novel DNA Gyrase Inhibiting Spiropyrimidinetriones: Benzisoxazole Fusion with N-Linked Oxazolidinone Substituents Leading to a Clinical Candidate (ETX0914)

Gregory S. Basarab, P. Doig, Vincent Galullo et al. · Journal of Medicinal Chemistry · 2015 · 68 citations

Bioorganic Chemistry, Molecular Biology, Clinical Candidate +20