Amy Kutschke

Responding to the challenge of untreatable gonorrhea: ETX0914, a first-in-class agent with a distinct mechanism-of-action against bacterial Type II topoisomerases

Gregory S. Basarab, Günther Kern, John McNulty et al. · Scientific Reports · 2015 · 104 citations · Full text

Medicine, Infectious Diseases, Pharmacology +16

Characterization of the Novel DNA Gyrase Inhibitor AZD0914: Low Resistance Potential and Lack of Cross-Resistance in Neisseria gonorrhoeae

Richard A. Alm, Sushmita D. Lahiri, Amy Kutschke et al. · Antimicrobial Agents and Chemotherapy · 2014 · 98 citations · Full text

Life Sciences, Infectious Diseases, Microbiology +15

<i>In Vitro</i> Antibacterial Activity of AZD0914, a New Spiropyrimidinetrione DNA Gyrase/Topoisomerase Inhibitor with Potent Activity against Gram-Positive, Fastidious Gram-Negative, and Atypical Bacteria

Michael D. Huband, Patricia A. Bradford, Linda G. Otterson et al. · Antimicrobial Agents and Chemotherapy · 2014 · 76 citations · Full text

Life Sciences, Medicinal Chemistry, Microbiology +17

Pharmacodynamic Profiling of a Siderophore-Conjugated Monocarbam in Pseudomonas aeruginosa: Assessing the Risk for Resistance and Attenuated Efficacy

Aryun Kim, Amy Kutschke, David E. Ehmann et al. · Antimicrobial Agents and Chemotherapy · 2015 · 76 citations · Full text

Medicine, Pharmacokinetics, Pharmacology +17

Discovery of Novel DNA Gyrase Inhibiting Spiropyrimidinetriones: Benzisoxazole Fusion with N-Linked Oxazolidinone Substituents Leading to a Clinical Candidate (ETX0914)

Gregory S. Basarab, P. Doig, Vincent Galullo et al. · Journal of Medicinal Chemistry · 2015 · 71 citations

Pharmacy, Medicinal Chemistry, Pharmacology +14