The structural basis for the specificity of pyridinylimidazole inhibitors of p38 MAP kinase

Keith P. Wilson, Patricia G. McCaffrey, Kathy Hsiao, +7

Chemistry & Biology

Drug TargetP38 Map KinaseBiochemistryPyridinylimidazole InhibitorsMedicine +8

A single amino acid substitution makes ERK2 susceptible to pyridinyl imidazole inhibitors of p38 MAP kinase

Ted Fox, Joyce T. Coll, Xiaoling Xie, +8

Protein Science

Cellular and biochemical characterization of VX-710 as a chemosensitizer

Ursula A. Germann, Dlna Shlyakhter, Valerie S. Mason, +7

Anti-Cancer Drugs

Medicinal ChemistryDrug Resistance AnalysisBioorganic ChemistryBiochemistryMdr1 Gene Product +12

Novel N-Linked Aminopiperidine Inhibitors of Bacterial Topoisomerase Type II: Broad-Spectrum Antibacterial Agents with Reduced hERG Activity

Folkert Reck, Richard A. Alm, Patrick Brassil, +16

Journal of Medicinal Chemistry

Reduced Herg ActivityAntimicrobial ChemotherapyPharmaceutical ChemistryDrug ResistanceMedicinal Chemistry +19

Responding to the challenge of untreatable gonorrhea: ETX0914, a first-in-class agent with a distinct mechanism-of-action against bacterial Type II topoisomerases

Gregory S. Basarab, Günther Kern, John McNulty, +20

Scientific Reports

The Discovery of VX-745: A Novel and Selective p38α Kinase Inhibitor

John P. Duffy, Edmund Harrington, Francesco G. Salituro, +18

ACS Medicinal Chemistry Letters

Discovery of Novel DNA Gyrase Inhibiting Spiropyrimidinetriones: Benzisoxazole Fusion with N-Linked Oxazolidinone Substituents Leading to a Clinical Candidate (ETX0914)

Gregory S. Basarab, P. Doig, Vincent Galullo, +10

Journal of Medicinal Chemistry

Bioorganic ChemistryMolecular BiologyClinical CandidatePharmacotherapyPharmaceutical Chemistry +18

Novel DNA Gyrase Inhibiting Spiropyrimidinetriones with a Benzisoxazole Scaffold: SAR and in Vivo Characterization

Gregory S. Basarab, Patrick Brassil, P. Doig, +8

Journal of Medicinal Chemistry

Pharmaceutical ScienceDrug TargetStaphylococcus AureusMolecular BiologyChemical Biology +17

Discovery of Efficacious <i>Pseudomonas aeruginosa</i>-Targeted Siderophore-Conjugated Monocarbams by Application of a Semi-mechanistic Pharmacokinetic/Pharmacodynamic Model

Kerry E. Murphy-Benenato, Pratik Bhagunde, April Chen, +23

Journal of Medicinal Chemistry

Lead CompoundsNew AgentsAntimicrobial ChemotherapyPharmacodynamic ModelingDrug Resistance +19

Synthesis of a Tetrahydronaphthyridine Spiropyrimidinetrione DNA Gyrase Inhibiting Antibacterial Agent - Differential Substitution at all Five Carbon Atoms of Pyridine.

Gregory S. Basarab, Vincent Galullo, Nancy DeGrace, +3

Organic Letters

Bioorganic ChemistryEngineeringOrganic ChemistryAntimicrobial ChemotherapyCarbon Atoms +17