Concepedia

A new class of angiotensin II receptor antagonists with a novel acidic bioisostere

Yasuhisa Kohara, Eiko Imamiya, Keiji Kubo, Takeo Wada, Yasuhiro Inada, Takehiko Naka

Bioorganic & Medicinal Chemistry Letters · 1995 · 56 citations · 8 references

DOI

Concepts

References

8

Pharmacological profile of a highly potent and long-acting angiotensin II receptor antagonist, 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4- yl]methyl]-1H-benzimidazole-7-carboxylic acid (CV-11974), and its prodrug, (+/-)-1-(cyclohexyloxycarbonyloxy)-ethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5- yl)biphenyl-4-yl]methyl]-1H-benzimidazole-7-carboxylate (TCV-116).

Yumiko Shibouta, Yasuhiro Inada, M Ojima et al. · Journal of Pharmacology and Experimental Therapeutics · 1993 · 213 citations

, , +13

Nonpeptide angiotensin II receptor antagonists. Synthesis and biological activity of benzimidazolecarboxylic acids

Keiji Kubo, Yasuhisa Kohara, Eiko Imamiya et al. · Journal of Medicinal Chemistry · 1993 · 135 citations · Full text

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Nonpeptide angiotensin II receptor antagonists. Synthesis and biological activity of potential prodrugs of benzimidazole-7-carboxylic acids

Yasuhisa Kohara, Y. Yoshimura, Yumiko Shibouta et al. · Journal of Medicinal Chemistry · 1993 · 129 citations

, , +13

Nonpeptide angiotensin II receptor antagonists. Synthesis and biological activity of benzimidazoles

Keiji Kubo, Yoshiyuki Inada, Yasuhisa Kohara et al. · Journal of Medicinal Chemistry · 1993 · 126 citations

, , +16

The Renin-Angiotensin System

Carlos M. Ferrario · Journal of Cardiovascular Pharmacology · 1990 · 91 citations

, , +17