Yumiko Shibouta

Pharmacological profile of a highly potent and long-acting angiotensin II receptor antagonist, 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4- yl]methyl]-1H-benzimidazole-7-carboxylic acid (CV-11974), and its prodrug, (+/-)-1-(cyclohexyloxycarbonyloxy)-ethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5- yl)biphenyl-4-yl]methyl]-1H-benzimidazole-7-carboxylate (TCV-116).

Yumiko Shibouta, Yasuhiro Inada, M Ojima et al. · Journal of Pharmacology and Experimental Therapeutics · 1993 · 213 citations

Pathophysiological role of endothelin in acute renal failure

Yumiko Shibouta, Nobuhiro Suzuki, Akio Shino et al. · Life Sciences · 1990 · 174 citations

Heart Failure, Acute Renal Failure, Renal Function +8

Candesartan (CV-11974) dissociates slowly from the angiotensin AT1 receptor

Mami Ojima, Yoshiyuki Inada, Yumiko Shibouta et al. · European Journal of Pharmacology · 1997 · 141 citations

Molecular Pharmacology, Angiotensin At1 Receptor, Molecular Physiology +9

Nonpeptide angiotensin II receptor antagonists. Synthesis and biological activity of potential prodrugs of benzimidazole-7-carboxylic acids

K. Kubo, Yasuhisa Kohara, Y. Yoshimura et al. · Journal of Medicinal Chemistry · 1993 · 129 citations

Oral Ba, Pharmaceutical Science, Oral Bioavailability +18

Protective Effects of Candesartan Cilexetil (TCV-116) Against Stroke, Kidney Dysfunction and Cardiac Hypertrophy in Stroke-Prone Spontaneously Hypertensive Rats

Y Inada, Takao Wada, M Ojima et al. · Clinical and Experimental Hypertension · 1997 · 106 citations

Hypertension, Cardiovascular Pharmacology, Pharmacotherapy +19