Keiji Kubo

Lansoprazole, a novel benzimidazole proton pump inhibitor, and its related compounds have selective activity against Helicobacter pylori

T Iwahi, Hiroshi Satoh, Megumi Nakao et al. · Antimicrobial Agents and Chemotherapy · 1991 · 278 citations · Full text

Bioorganic Chemistry, Selective Activity, Biochemistry +14

Synthesis and Angiotensin II Receptor Antagonistic Activities of Benzimidazole Derivatives Bearing Acidic Heterocycles as Novel Tetrazole Bioisosteres

Yasuhisa Kohara, Keiji Kubo, Eiko Imamiya et al. · Journal of Medicinal Chemistry · 1996 · 270 citations

Pharmacological profile of a highly potent and long-acting angiotensin II receptor antagonist, 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4- yl]methyl]-1H-benzimidazole-7-carboxylic acid (CV-11974), and its prodrug, (+/-)-1-(cyclohexyloxycarbonyloxy)-ethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5- yl)biphenyl-4-yl]methyl]-1H-benzimidazole-7-carboxylate (TCV-116).

Yumiko Shibouta, Yasuhiro Inada, M Ojima et al. · Journal of Pharmacology and Experimental Therapeutics · 1993 · 213 citations

In Vitro Antagonistic Properties of a New Angiotensin Type 1 Receptor Blocker, Azilsartan, in Receptor Binding and Function Studies

Mami Ojima, Hideki Igata, Masayuki Tanaka et al. · Journal of Pharmacology and Experimental Therapeutics · 2010 · 146 citations

Inhibition of rabbit aortic angiotensin II (AII) receptor by CV-11974, a new nonpeptide AII antagonist

Noda Masakuni, Shibouta Yumiko, Yoshiyuki Inada et al. · Biochemical Pharmacology · 1993 · 143 citations

Hypertension, Cardiovascular Disease, Medicine +7