Synthesis and Angiotensin II Receptor Antagonistic Activities of Benzimidazole Derivatives Bearing Acidic Heterocycles as Novel Tetrazole Bioisosteres

Yasuhisa Kohara, Keiji Kubo, Eiko Imamiya, +3

Journal of Medicinal Chemistry

Pharmacological profile of a highly potent and long-acting angiotensin II receptor antagonist, 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4- yl]methyl]-1H-benzimidazole-7-carboxylic acid (CV-11974), and its prodrug, (+/-)-1-(cyclohexyloxycarbonyloxy)-ethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5- yl)biphenyl-4-yl]methyl]-1H-benzimidazole-7-carboxylate (TCV-116).

Yumiko Shibouta, Yasuhiro Inada, M Ojima, +7

Journal of Pharmacology and Experimental Therapeutics

T4 RNA ligase mediated preparation of novel "chemically misacylated" tRNAPhes

Thomas G. Heckler, Li Chang, Y Zama, +3

Biochemistry

Nonpeptide angiotensin II receptor antagonists. Synthesis and biological activity of benzimidazolecarboxylic acids

Keiji Kubo, Yasuhisa Kohara, Eiko Imamiya, +5

Journal of Medicinal Chemistry

Biological ActivityMolecular PharmacologyMedicinal ChemistryAngiotensin IiPharmacological Study +13

Nonpeptide angiotensin II receptor antagonists. Synthesis and biological activity of potential prodrugs of benzimidazole-7-carboxylic acids

K. Kubo, Yasuhisa Kohara, Y. Yoshimura, +4

Journal of Medicinal Chemistry

Oral BaPharmaceutical ScienceOral BioavailabilityChemical ModificationPeptide Science +16

Nonpeptide angiotensin II receptor antagonists. Synthesis and biological activity of benzimidazoles

Keiji Kubo, Yoshiyuki Inada, Yasuhisa Kohara, +6

Journal of Medicinal Chemistry

Biological ActivityMolecular PharmacologyMedicinal ChemistryAngiotensin IiBenzimidazole Ring +11

Dipeptide formation with misacylated tRNAPhes.

Thomas G. Heckler, Y Zama, Takehiko Naka, +1

Journal of Biological Chemistry

Antihypertensive effects of a highly potent and long-acting angiotensin II subtype-1 receptor antagonist, (+-)-1-(cyclohexyloxycarbonyloxy)ethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1H- benzimidazole-7-carboxylate (TCV-116), in various hypertensive rats.

Yasuhiro Inada, Takeo Wada, Yumiko Shibouta, +7

Journal of Pharmacology and Experimental Therapeutics

A new class of angiotensin II receptor antagonists with a novel acidic bioisostere

Yasuhisa Kohara, Eiko Imamiya, Keiji Kubo, +3

Bioorganic & Medicinal Chemistry Letters

Molecular PharmacologyMedicinePhysiologyCardiovascular PharmacologyNovel Acidic Bioisostere +7

Preparation of '2,('3)-O-Acyl-pCpA derivatives as substrates for T4 RNA ligase-mediated “chemical aminoacylation”

Thomas G. Heckler, Li Chang, Y Zama, +2

Tetrahedron

-O-acyl-pcpa DerivativesBiosynthesisEngineeringNucleic Acid ChemistryBiochemistry +9